medical device manufacturers

Abstract: Lung tumor segmentation plays a vital role in early detection and treatment planning of lung cancer. Although state-of-the-art deep learning models achieve high dice score coefficients (DSC), each forward pass requires computing large amounts of floating point operations, making them computationally expensive, requiring GPU acceleration, and having slow inference speed, limiting real-world clinical deployment. We propose a lightweight, energy-efficient model that leverages the ENet architecture for its real-time inference capability and low computational cost, enhanced with UNet-style skip connections between encoder and decoder stages for feature reuse and the lightweight Convolutional Block Attention Module (CBAM) for improved feature representation. The model is trained on publicly available data from The Cancer Imaging Archive (TCIA) via the Medical Segmentation Decathlon Challenge (MSD) and evaluated on the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI) dataset. Our model achieves a DSC of 0.90812 (threshold of 0.5) with its compact architecture of 430,052 parameters and 0.549 Giga Multiply-Accumulate operations (GMAC), making it up to 10 times faster, requires 79 times less GMAC than UNet, and has 22 times fewer parameters than SegNet. These characteristics make it well-suited for deployment in clinical settings where computational resources are limited and decrease the cost of utilizing such a system. Additionally, the explainable AI technique of Grad-CAM is used to provide visual interpretability of the model's predictions and to identify regions where segmentation performance requires improvement.

Abstract: Current light-based devices, such as laser hair removal, intense pulsed light (IPL), vascular laser therapy, and dermatologic phototherapy, are widely used in clinical dermatology but rely heavily on subjective manual parameterization or uncalibrated point-based colorimeters. To overcome these limitations, this work presents a unified system for hair segmentation and skin characterization in macroscopic dermatological images. Unlike most existing literature that relies on dermoscopic datasets captured under highly controlled conditions, our approach is specifically designed for macroscopic images that replicate real clinical laser treatments. The proposed pipeline integrates a custom-trained variant of the YOLOv9 deep learning architecture for instance segmentation and classical image processing within a single workflow to extract objective skin and hair parameters such as phototype, hair density, color, and thickness. A color calibration stage using spectrophotometric measurements ensures accurate feature estimation regardless of illumination conditions. Experimental results show competitive segmentation metrics (mAP@50 $\approx$ 0.80) on a custom dataset featuring short, shaved hairs, typical of pre-treatment scenarios. These findings demonstrate the feasibility of the proposed pipeline in providing the objective, foundational skin and hair features required for future automated laser parameterization, paving the way for its extension to broader light-based medical therapies.

Abstract: As wearable and digital health systems increasingly generate longitudinal physiological records, communicating these observations in patient-accessible language remains a significant challenge. Large Language Models (LLMs) offer a promising mechanism for translating structured clinical information into readable narratives, but this process may introduce semantic drift, where clinically precise meaning is distorted during simplification. We investigate evidence-grounded health summarization for menstrual health monitoring using a constrained generation framework that combines structured evidence conditioning with Retrieval-Augmented Generation (RAG) using a prompt-based constrained generation framework. We evaluate semantic alignment using Natural Language Inference (NLI), atomic factuality metrics, and readability measures. Across three LLMs and 4,500 generated summaries, explicit grounding constraints consistently improve clinical alignment, particularly by improving uncertainty preservation and, once faithfulness is evaluated against retrieved evidence, generally preserving or improving faithfulness, while effects on omission remain model-dependent. We also find that improved clinical alignment comes at the cost of increased reading difficulty and medical terminology. These findings highlight the need to jointly evaluate faithfulness, uncertainty preservation, and readability when developing patient-facing medical LLM systems.

Abstract: Ophthalmic clinical decision support requires fast, accurate, and privacy-preserving inference, yet autoregressive large language models (LLMs) incur substantial latency and computational overhead for decisions among predefined actions. We therefore investigate a decision-oriented alternative to generative reasoning. Specifically, we first introduce RetiJev-Data, a source-grounded ophthalmology corpus comprising 78,158 clinical-decision and diagnosis questions derived from articles in PubMed Central and a MeSH vocabulary covering 531 eye diseases, and 50,074 guideline-grading questions spanning 11 grading systems, along with a 24,662-question evaluation benchmark. Based on this, we develop RetiJev, a family of 0.8B-9B decision models that directly score candidate answers without autoregressive decoding. Across all model sizes, RetiJev outperforms both a 27B LLM and the commercial Jev 1.13 decision model on guideline grading by 10.4-23.0 points. RetiJev-9B further achieves the highest accuracy on clinical decisions, improving over both baselines by 5.4-6.5 points while matching them on diagnosis. It answers a case in 158 ms on one GPU, 3.5x faster than LLM generation and 470x faster than reasoning. Models are released at https://github.com/Awenbocc/RetiJev.

Abstract: Diabetic retinopathy is a leading cause of preventable blindness, yet access to regular screening remains limited worldwide. AI offers a scalable approach, but its performance can be sensitive to image quality and acquisition conditions. In a Brazilian cohort of 8,524 patients, retinal images acquired with the Nikon NF5050 were more than twice as likely to have inadequate image quality compared with those acquired with the Canon CR-2, despite refurbished Canon systems costing more than twice as much as Nikon systems. This potential cost-quality trade-off highlights an important consideration for the reliability of AI systems deployed across heterogeneous imaging systems. Using a frozen pretrained retinal foundation model, we systematically evaluate whether camera-associated performance differences persist across 12 retinal disease classification tasks, four input resolutions, and five downstream classifiers. We find that camera-associated performance differences vary substantially across tasks, and that neither higher input resolution nor classifier choice consistently mitigates cross-camera variation. These findings identify camera platform as a potentially overlooked source of performance variability, with implications for the safety and reliability of retinal AI when deployed across heterogeneous imaging systems. We release all source code, evaluation scripts, and per-task results on GitHub to support reproducible benchmarking.

Abstract: Serial MRI is routinely performed in current clinical practice for disease surveillance and applications such as MR-guided radiotherapy. However, long MRI scan times increase costs and limit patient access, making accelerated image reconstruction of broad clinical importance. Previous scans of the same patient contain image information highly correlated with the current exam, yet existing reconstruction methods rarely exploit this information. Major challenges in the effective use of prior scans include inter-visit misregistration, pathological changes, and image phase variation. In this work, we propose Longitudinal Guided Group Sparsity (LGGS), an interpretable deep-learning framework for longitudinally informed MRI reconstruction derived from classical group sparsity. The prior scan is incorporated into the reconstruction regularizer through learned phase-invariant circulant attention that identifies corresponding features across exams. This formulation provides robustness to local in-plane and through-plane misregistration as well as inter-visit phase variation. Across acceleration rates, LGGS achieves state-of-the-art performance on longitudinal T1-weighted multi-coil brain MRI data, outperforming the evaluated unguided and longitudinally informed reconstruction methods, with substantially fewer learned parameters. We further evaluated the contributions of multiple guide slices and phase-invariant similarity and demonstrated that accelerated prior images can also serve as effective guides with minimal degradation in reconstruction quality.

Abstract: Deep learning for medical image restoration is often constrained by the need for paired training data. Acquiring perfectly registered clean-noisy radiographs in vivo is impractical due to patient motion and radiation-dose limits. To address this, we employ a self-supervised Noise2Noise paradigm that trains on independently corrupted observations without paired clean images. We propose Denoise X, a lightweight self-supervised U-Net model (7.79M parameters) for suppressing quantum mottle and electronic readout noise in low-dose chest radiographs. It is trained on the NIH ChestX-ray14 dataset (112,120 images) using a stochastic Poisson-Gaussian noise simulator. Zero-shot evaluation on the unseen Montgomery County dataset achieved a PSNR of 36.09 dB and SSIM of 0.8806, outperforming the Bilateral filter while preserving high-frequency anatomical details. Using patch-wise inference, Denoise X processes native-resolution chest radiographs in ~2.2 s per image on a Tesla P100 GPU. Cross-domain evaluation on the Shenzhen dataset achieved 36.44 dB PSNR and 0.9099 SSIM, showing strong generalization. For resource-constrained deployment, the model was converted into a 31.16 MB ONNX model for efficient CPU inference on non-DICOM images.

Abstract: Clinical screening for diabetic retinopathy proceeds in stages, yet most automated systems grade fundus images with a single black-box network. Three gaps remain: (i) lesions differ widely in size and contrast, but segmenters typically apply the same blocks to all; (ii) ungradable images are usually excluded or treated as an extra class, and lesion-aware graders seldom test whether lesions drive the grade; (iii) staged systems often report each stage only on the images reaching it, leaving propagated errors unmeasured. HierarchiRetina, a screening, segmentation and grading cascade with inspectable stage outputs, addresses each gap. First, HSMoE-AUNet is a U-Net whose skip, bottleneck and decoder blocks are sparse mixtures of heterogeneous experts, with lesion-matched types, counts and losses; SwinHRUNetPP, a dual-encoder vessel segmenter, uses a field-of-view-restricted loss. Second, LG-DRG separates gradability from ordinal severity and lets lesion masks query the image through gated cross-attention. Third, an end-to-end evaluation counts screening misses as errors and traces each error to its stage. Pooled Dice ranged from 0.184 (microaneurysms) to 0.579 (exudates); vessel Dice was 0.731. On 58,689 held-out images from six datasets, end-to-end quadratic weighted kappa was 0.804, with referral sensitivity 0.832 at specificity 0.947, and the screening gate caused 66% of errors. In ablations, the grade ignored the masks, even with the cross-attention gate started open. On all 4,105 official DDR test images, six-class accuracy was 85.6%, above the best published six-class result we found (83.8%). Staged screening systems should be evaluated end-to-end, with stage attribution and mask ablation, before clinical deployment.

Abstract: Accurate and efficient analysis of dental radiographs has become increasingly important for disease diagnosis and clinical decision making. In particular, dental radiographs segmentation plays a critical role as it is challenging due to several reasons, such as low contrast, noise in the images, variations in the image quality, etc. Previous studies have primarily addressed these challenges using convolutional neural networks (CNN)-based models. However, direct comparison of these segmentation models is still challenging due to the variations among the experimental settings. Therefore, we mainly compared four segmentation models, including Pyramid Scene Parsing Network (PSPNet), DeepLabV3, UNet, and UNet++, through a fair, controlled experimentation setting under varying conditions such as image sizes and batch sizes. For this, we used 1269 dental radiography images, and prior to training, we implemented a series of preprocessing techniques. To assess the models, we used several metrics, including Dice coefficient (DICE), Intersection over Union (IoU), accuracy, precision, training and validation losses. According to our results, UNet++ demonstrated the highest IoU score of 0.6719, and a DICE value of 0.7869, showing superior results in terms of segmentation, specifically when configured with an image size of 300x300 and a batch size of 16. In addition, we also explored the effect of image resolutions and batch sizes on model performance and accuracy under different architectures. Therefore, this study provides insights into the strengths of different segmentation models and the potential of deep learning-based semantic segmentation methods for improving automated dental radiograph analysis.

Abstract: Sparse-view Cone-Beam Computed Tomography (CBCT) reconstruction is essential for reducing radiation dose and scan effort, but remains underconstrained due to limited projection information. Recent 3D Gaussian Splatting (3DGS)-based CBCT reconstruction methods rely on gradient-driven densification, which becomes unstable under sparse acquisition and often leads to over-smoothed structures. We propose AD-GS, an Anatomical Density-guided 3D Gaussian Splatting framework that formulates Gaussian densification as an attenuation-aware Markov Chain Monte Carlo (MCMC) sampling process. By interpreting Gaussians as samples from an underlying anatomical attenuation distribution, AD-GS adaptively concentrates representation capacity in high-attenuation regions, enabling sharper structural boundaries under sparse projections. To further constrain reconstruction, we incorporate a semantic regularization based on zero-shot features from Segment Anything in Medical Images, enforcing multi-view consistency through semantic priors. Experiments on the ToothFairy3 dental CBCT dataset demonstrate that AD-GS achieves superior structural fidelity and boundary preservation compared with existing 3DGS-based approaches under sparse-view settings within the dental and maxillofacial setting. Code is available at https://github.com/yulinjiaxue/AD-GS-BMVC2026.

Abstract: Objective: We investigate whether accounting for epistemic uncertainty can improve the reliability of automated defect detection in medical device manufacturing. Methods: We consider a machine learning framework that operates on heterogeneous manufacturing and device-report data represented with Knowledge Graphs. To mitigate errors arising from uncertainty in the decision model, we analyze a principled rejection strategy to abstain from predictions whose estimated epistemic uncertainty exceeds a specified threshold. We evaluate the approach using standard synthetic benchmarks and real-world medical device report data. Results: The theoretical results establish the validity of the method characterizing the regimes under which it is expected to be effective. Empirically, the rejection strategy enables explicit control of coverage, that is, the proportion of samples for which the model issues predictions, while improving performance on the retained samples. On 266,170 real-world FDA MAUDE device reports, a 10% abstention rate reduces classification error by 48%, and more aggressive rejection (approximately 70% coverage) yields near-perfect accuracy on the retained samples. On standard synthetic manufacturing benchmarks, abstaining on 9% of the decisions, our approach reduces the risk up to 63% compared with the standard no-abstention approach. Conclusions: Abstaining from predictions with high epistemic uncertainty can provide a practical tool for controlling the reliability of machine learning-based defect detection, especially in high-stakes medical device manufacturing applications. Significance: Uncertainty-aware defect detection may support safer and more reliable quality assurance in medical device manufacturing by identifying cases that require additional inspection rather than issuing potentially harmful predictions.

Abstract: Learned surgical simulators and world models can roll out plausible procedural futures, but they carry no grounded estimate of how often interventional devices actually harm patients. We propose treating population-scale adverse-event surveillance as a distinct belief layer of the surgical digital twin, and we evaluate a federated Bayesian protocol for learning it under formal privacy guarantees. Each site holds per-class Gamma-Poisson posteriors over adverse-event rates and exchanges only Rényi-differentially-private natural-parameter updates. We benchmark on the complete FDA MAUDE cohort for thrombus-retrieval catheters (product code NRY): 8,617 reports, of which 6,491 are classified by transparent keyword rules into five thrombectomy complication classes and partitioned across $K=8$ manufacturer sites. At a matched privacy budget of $(\\varepsilon \\approx 2.09, \δ= 10^{-5})$, the conjugate protocol attains a held-out Poisson score of -5.78 per test event versus -26.58 for FedAvg with differential privacy. The non-private federated model also outperforms centralized pooling (+3.19 vs +2.93), evidence that manufacturer-specific complication profiles are real and that federation preserves them. Because MAUDE lacks procedure denominators, outputs are relative rate orderings rather than absolute risks, and we report all privacy-utility operating points.

Abstract: A significant problem in endoscopic image analysis is that the machine learning (ML) models used for this purpose usually underperform when applied on images acquired from endoscopes that are different from those used to acquire the images of their training set. The main difference of the images originating from different endoscopes is their color distributions, which depend both on the image sensors and the light sources used. Although previous studies have highlighted this challenge, to the best of our knowledge it has not been previously explicitly tackled. This study focuses on this problem and proposes very simple but impactful method. It implements a reference-based image harmonization that reduces global appearance differences between endoscopic datasets. Specifically, it extracts global color statistics from a chosen reference dataset in the CIE-Lab color space and applies a statistical channel-wise transformation to map each target image toward the appearance of the images of the reference dataset. The method is evaluated in the context of polyp detection in both flexible colonoscopy and capsule endoscopy datasets using a dataset-level cross validation protocol. The results indicate that the proposed harmonization consistently improves cross-dataset performance up to 30.7%, outperforming relevant baseline and state-of-the-art methods. The results indicate that a substantial part of the generalization gap is driven by low-level appearance variation that can be mitigated without retraining.

Abstract: Multi-structure segmentation of the uterus is important for computer-assisted screening, diagnosis, and treatment planning of uterine diseases, where ultrasound and MRI provide complementary clinical information. However, developing a unified model across these modalities is challenging due to their substantially different image appearances, anatomical contexts, spatial resolutions, and label spaces. Moreover, existing datasets often define different segmentation targets, making joint learning challenging and potentially leading to negative transfer across heterogeneous tasks. To this end, we propose a Topology-informed Prompt-conditioned Universal Segmentation (TPUS) framework for segmenting multiple uterine structures across ultrasound and MRI. TPUS introduces a graph-based multi-dataset backbone comprising modality-specific stems and a modality-shared graph-based encoder-decoder to support modality-sensitive input adaptation, structural feature reasoning, and joint representation learning across heterogeneous uterine segmentation tasks. In addition, TPUS uses task-aware class prompts to condition the segmentation process for different datasets and label spaces, a dynamic convolutional adaptation module to generate task-specific output responses, and a topology-informed loss to encourage anatomically consistent predictions. Experiments on a uterine ultrasound dataset and a T2-weighted uterine myoma MRI dataset demonstrate that TPUS achieves Dice scores of 0.898 and 0.693 on the two held-out test sets, respectively, outperforming several generic and universal segmentation baselines. Source code can be accessed at https://github.com/YonghengSun1997/TPUS.

Abstract: Radiology report generation models can produce fluent text while still containing finding-level inaccuracies. Diagnosis-driven methods improve generation by conditioning on predicted findings, but these predictions do not directly modify the visual patch features provided to the decoder, and global gating applies the same modulation across spatial locations. We introduce a Position-Aware Gate (PAG) that uses predicted finding representations to modulate visual patches spatially without region supervision. We also propose a Decoder-level Supervised Contrastive Loss (DSCL) that structures decoder representations using shared positive findings rather than instance identity. On MIMIC-CXR, PAG+DSCL improves clinical efficacy (CE) F1 from 0.484 to 0.502 over a matched global-gate reference, while PAG and DSCL individually reach 0.491 and 0.495. Without additional fine-tuning, the combined model achieves 0.226 CE F1 on IU X-Ray, compared with 0.211 reported by PromptMRG.

Abstract: The application of machine learning to dermatology has grown substantially in recent years, moving beyond proof-of-concept studies toward potential applications. However, clinical dermatology remains a challenging and still open problem. Diagnostic assessment is often ambiguous, and skin lesions exhibit high variability, compounded by differences in acquisition modality, device quality, and patient demographics. These factors hinder the development of robust models suitable for safe and equitable clinical use. To support translation into practice, it is essential to systematically evaluate how contemporary models generalize across heterogeneous data sources. In this work, we benchmark a diverse set of architectures on recent dermatology datasets, spanning dermoscopic images and smartphone-based clinical photographs. We assess the robustness of recent general-purpose and medical vision-language models, as well as foundation models, and compare them against task-specific dermatology classifiers, including embedding-based approaches and convolutional neural networks. Our study provides an evaluation of model performance under distribution shifts, modality changes, and demographic variability. By quantifying the gap between current state-of-the-art models and the requirements of clinical deployment, we aim to contribute to the development of reliable, accessible, and clinically applicable AI systems for dermatology.

Abstract: Deep learning classifiers for dermoscopic skin lesions often reach high in-distribution accuracy while quietly relying on spurious background cues such as skin tone, device vignetting, and embedded rulers, rather than on lesion morphology. This undermines robustness and fairness across skin tones. This work asks whether Explainable AI (XAI), typically used only to audit a finished model, can instead be repurposed as an active training signal that corrects this shortcut without sacrificing diagnostic accuracy. We introduce CAMEO (Class Activation Mapped Equitable Overlay), a framework that improves skin-lesion classification by selecting stable model explanations and using them to separate lesions from their backgrounds. It then replaces the background with realistic synthetic skin while keeping the lesion unchanged. On HAM10000 and dark-skin ISIC images, CAMEO maintained accuracy while reducing background-driven errors by nearly four times. It also made the model's attention more consistent when backgrounds changed. Results across multiple tests show that reducing reliance on background information improves robustness, with Fitzpatrick-based backgrounds providing a realistic and interpretable approach. Results show that XAI-guided augmentation can make dermoscopic classifiers measurably more robust and fair at no cost to accuracy. They also clarify that it is the mechanism and not the specific tone palette that matters, and that the lasting contribution of XAI here lies in stability-screened, annotation-free lesion localisation rather than in the robustness number itself.

Abstract: Clinical CT and UHRCT cannot resolve individual trabeculae, whereas synchrotron radiation microCT (SRμCT) provides 3.2μm high-resolution references but is not applicable for in vivo imaging. The two domains differ by 31.25x in resolution, are only coarsely paired, and have drastically different data volumes. Moreover, clinical UHRCT suffers from severe partial volume effects, strong noise, and beam hardening/scatter artifacts, while SRμCT is nearly free. Existing super-resolution networks and pretrained-prior methods underperform because they target pixel generation--diverse details and SSIM/PSNR--and do not explicitly model these physical differences. This indicates that 32x super-resolution via pixel generation is intrinsically ill-posed. We propose a paradigm shift from pixel generation to topological inference: deterministically predicting invariant microstructures from macro-scale low-resolution inputs, evaluated by morphological parameters. We realize this paradigm via structural dual super-resolution, coupling forward physical degradation (micro-to-macro) with inverse structural inference (macro-to-micro) through structural duality constraints. The method is an end-to-end, few-shot, compact structural dual network (SDN), comprising a bidirectional modeling network for forward degradation and inverse reconstruction, a pyramid structural consistency discriminator, and four structural duality constraints. On the testset, SDN achieves morphological parameters largely consistent with SRμCT across 7 metrics, enabling clinical UHRCT with micro-imaging-level morphological quantification, with SSIM reaching 0.8. Trained on 3.2μm SSRF data, the model generalizes well to 3.25μm BSRF data from an independent source, validating cross-source generalization and confirming that the designed network achieves trustworthy structural inference rather than pixel generation.

Abstract: Deep learning models for Alzheimer disease (AD) classification routinely report near-perfect discrimination, yet few are shown to rest on AD-relevant neurobiology rather than on dataset artifacts, subject-level leakage, or non-brain image content. We present a fusion network combining T1 MRI and FDG PET across axial, coronal, and sagittal planes, trained on ADNI consists of 554 paired subjects. The fusion model reaches AUC 0.962, accuracy 0.909, and F1 0.891, competitive with recent 3D CNN and multimodal transformer systems at substantially lower cost. We first quantify how much modality, plane and slice geometry matter. A validation-only search over slice centres and neighbour spacings moves AUC by 0.180 for MRI and 0.078 for PET, selecting narrow spacing for MRI and wide spacing for PET, with the chosen coronal centres falling on the hippocampal body and on the posterior cingulate respectively. The contribution, however, is the evidence layer built around that number. Shortcut controls collapse the model to AUC 0.622 (silhouette), 0.608 (exterior), and 0.500 (blank), and a label-permutation null yields 0.456. Forward region-of-interest (ROI) ablation shows that masking medial temporal cortex in MRI and the posterior default-mode network (DMN) in PET produces the largest shift in the AD logit, while area-matched controls remain indistinguishable from that null. Reverse ROI ablation shows that the medial temporal lobe alone retains 89.2% of above-chance discrimination in MRI and the posterior DMN alone retains 79.0% in PET. A quantitative comparison of attribution methods shows occlusion sensitivity reaching 3.5-5.0* enrichment inside a priori AD regions against 0.10-0.43* in controls. Ablation and attribution independently establish a biologically correct double dissociation: hippocampal evidence is carried by MRI, posterior cingulate evidence by PET.

Abstract: Developing optimized machine-learning algorithms for edge devices with limited computational and memory resources is challenging, time-consuming, and highly dependent on device-specific constraints. In this work, we streamline an edge ML workflow to enable rapid development, optimization, and deployment of machine-learning (ML) models directly on the WeBe Band, a wrist-worn wearable device designed for multimodal physiological data monitoring. The proposed system automatically generates hardware-efficient ML models that can be easily integrated into the WeBe core firmware, supporting AutoML, hardware-aware quantization, and performance profiling to build models that meet desired latency targets while remaining compatible with device memory and power limitations. The proposed framework tightly integrates the open-source Piccolo AI ecosystem with an automated pipeline that generates deployable firmware artifacts, performs hardware-aware model compilation, and supports over-the-air (OTA) deployment. The system supports multiple lightweight model classes, including classical machine-learning algorithms and neural networks, and provides built-in on-device profiling tools to evaluate inference latency and memory footprint under realistic execution conditions. Experimental results demonstrate clear trade-offs between model complexity and deployability on a microcontroller, showing that classical models offer strong real-time performance while lightweight neural networks require careful resource management. Rather than proposing new learning architectures, the current work mainly focuses on system-level automation, deployability, and enabling researchers and developers to rapidly iterate on models and evaluate them directly on target hardware. Although demonstrated on the WeBe Band platform, the workflow is designed to be extensible to other ML-powered edge devices.

Abstract: Most minimally invasive surgery is still performed with hand-held laparoscopic instruments, and the surgeon's instrument kinematics are lost when the operation ends; only the endoscope video is kept. This paper presents an end-to-end pipeline that captures this motion in the operating room and uses it to train a surgical robot policy, validated on live animals. We introduce a surgical instrument-state logger that mounts on the shaft of a standard laparoscopic instrument and recovers its pose and jaw state from an inertial sensor, a time-of-flight sensor and a Hall sensor, with no external camera or tracker. A data pipeline measures the latency of every sensor channel against a robot ground truth and aligns the channels before forming observation-action pairs. On these demonstrations we train a diffusion policy with a fine-tuned DINOv3 backbone, selecting its design by closed-loop rollouts in a physics simulator reconstructed from depth maps of an ex-vivo rabbit appendix. The policy is then retrained on 849 in-vivo demonstrations from four live rabbits and deployed on four additional live rabbits with electrosurgery armed. With the surgeon selecting the surgical phase, the policy completed the appendectomy in three of the four animals. The results show that demonstrations recorded from a surgeon's own instruments are sufficient to train, select and deploy a bimanual surgical policy in vivo. The robot serves only as the timing reference for sensor calibration and as the executor, and collects no demonstrations. Both demonstration corpora are released to support future surgical robot learning research.

Abstract: Robotic ultrasound (US) calibration is essential for accurately relating US images to the robot coordinate system, but accurate and automated calibration remains challenging because existing methods often require complex phantoms or external 3D trackers. In this work, we develop a tracker-free robotic US calibration framework using a spherical-marker phantom and a highly automated perception pipeline for sphere-center localization. The proposed threshold-free image-processing method localizes the spherical feature based on each US image's intensity distribution, eliminating hand-tuned intensity thresholds and improving robustness across imaging settings without per-system retuning. Multi-pose observations of the spherical fiducial are then used to estimate the US-to-EE transformation without external tracking or prior localization of the sphere center in the robot base frame. We validate the proposed framework on a robotic US platform through repeated sphere scans and further assess the calibrated system using geometrically distinct phantoms with known CAD models. Across 12 cross-validation folds, single-marker calibration achieved sphere-center accuracy and precision of $1.75\pm0.51$ mm and $0.85\pm0.11$ mm, respectively, compared with $1.72\pm0.51$ mm and $0.84\pm0.12$ mm for three-marker calibration. Across the three reconstruction sets, the single-marker calibration yielded pooled post-registration point-to-surface MAE$\pm$SD values of $0.41\pm0.35$ mm for the cone and $0.50\pm0.41$ mm for the triangular prism, closely matching the three-marker results of $0.40\pm0.35$ mm and $0.48\pm0.40$ mm, respectively.

Abstract: Automatic tooth segmentation and FDI numbering on panoramic radiographs underpins computer-assisted dental diagnosis, yet which factors govern performance remains unclear. We assemble a corpus of 1,422 panoramic radiographs containing 42,142 expert-delineated tooth polygons across the 32-class FDI taxonomy, annotated by 30 dental practitioners and independently reviewed by two others, and use it to isolate input resolution, architecture and anatomical priors under a single evaluation protocol. First, resolution dominates: across a controlled 640/1024/1280 ablation, mask mAP50-95 rises 0.656 -> 0.710 -> 0.717 while mAP50 stays flat at ~0.982. Both gains are significant under a paired bootstrap over images (p < 0.001, p = 0.024); neither mAP50 change is distinguishable from zero. Added resolution buys boundary precision, not detection. Second, architecture is nearly irrelevant in-domain: a query-based transformer with 2.1x the parameters is statistically equivalent to a one-stage detector (95% CI [-0.0064, +0.0064]), only marginally better under domain shift, 5.5x slower on CPU and not executable under standard ONNX runtimes. Third, three targeted interventions fail: a LoRA-adapted self-supervised encoder underperforms, a promptable foundation segmenter degrades masks by 39%, and globally optimal anatomical label assignment yields +0.0007 despite correcting a constraint violated in 40% of out-of-domain predictions. Zero-shot transfer to an independent multi-centre cohort, verified overlap-free, costs 62% of mask mAP50-95 but only 18% of mAP50, reproducing the dissociation. Decomposing masks along the tooth axis localises the residual error to the apical third. Boundary precision is therefore the binding constraint, and effort is better directed at resolution and acquisition diversity than at architectural novelty.

Abstract: Automated needle-loop hooking is a critical step in flexible microelectrode (FME) implantation. This paper presents MicroHookACT, an imitation learning-based visuomotor policy for automated 3D hooking under monocular microscopic vision. First, a unidirectional hooking strategy exploits defocus cues and optical-axis guidance to enable palpation-free precise alignment and contact-rich threading. Second, an action-supervised object attention module built on a frozen ViT backbone learns to focus on the micro-needle tip and micro-loop directly from human demonstrations, without requiring manual visual annotations for training. Third, attention-centered global coarse and local fine features are dynamically weighted according to predicted action progress, enabling a single ACT policy to adapt to changing defocus blur and visual requirements throughout the operation. In the experiments, visuomotor policies were trained on 60 human demonstrations and evaluated under five setups with varying difficulties. Our MicroHookACT framework achieved the highest overall success rate of 96.7\% with an average execution time of 11.5 s. These results demonstrate the potential of visuomotor policy learning for micron-level control under varying operating conditions.

Abstract: In this work, we present a computational model to investigate transdermal insulin delivery using coated microneedles. A detailed skin geometry incorporating a coated microneedles was developed to analyze insulin release through the different skin layers and to evaluate the influence of key transport parameters. The model represents the major skin layers: the stratum corneum, viable epidermis, and dermis. Unstructured grids were used to achieve a reliable resolution of the model. The simulations provide insights into the permeation of insulin from the coated microneedles and the transport and distribution across the different skin layers. Finally, the simulation results were compared with experimental data to evaluate the predictive capability of the model.

Abstract: An artificial organ carries failure consequences on the scale of an aircraft or a reactor, but the software driving it is rarely held to the same standard. Teams building them rely on testing, which only reaches the failure modes someone thought of in advance. In a pump or controller that runs inside a patient for months, the dangerous cases are the ones nobody anticipated. Formal verification closes that gap. Applied to the device's software, it proves the code meets its specification for every execution that specification allows, and where a proof fails, it returns the exact input sequence that breaks it. The same methods already protect rail, aviation, and nuclear control systems, and they extend the IEC 62304 lifecycle that a manufacturer already follows rather than replacing it. In this paper, we explore how to apply formal verification to artificial organs, stage by stage, and what each technique actually guarantees about the device.

Abstract: The heightened prevalence of respiratory disorders, particularly exacerbated by a significant upswing in fatalities due to the novel coronavirus, underscores the critical need for early detection and timely intervention. This imperative is paramount, possessing the potential to profoundly impact and safeguard numerous lives. Medically, chest radiography stands out as an essential and economically viable medical imaging approach for diagnosing and assessing the severity of diverse Respiratory Disorders. However, their detection in Chest X-Rays is a cumbersome task even for well-trained radiologists owing to low contrast issues, overlapping of the tissue structures, subjective variability, and the presence of noise. To address these issues, a novel analytical model termed Exponential Pixelating Integral is introduced for the automatic detection of infections in Chest X-Rays in this work. Initially, the presented Exponential Pixelating Integral enhances the pixel intensities to overcome the low-contrast issues that are then polar-transformed followed by their representation using the locally invariant Mandelbrot and Julia fractal geometries for effective distinction of structural features. The collated features labeled Exponential Pixelating Integral with dually characterized fractal features are then classified by the non-parametric multivariate adaptive regression splines to establish an ensemble model between each pair of classes for effective diagnosis of diverse diseases. Rigorous analysis of the proposed classification framework on large medical benchmarked datasets showcases its superiority over its peers by registering a higher classification accuracy and F1 scores ranging from 98.46 to 99.45% and 96.53-98.10% respectively, making it a precise and interpretable automated system for diagnosing respiratory disorders.

Abstract: Soft robots offer safe and adaptive interaction with humans and unstructured environments through their inherent ability to deform and comply. Pneumatic actuators are one way to build soft robots. They are typically made from soft silicone materials and are especially effective for driving such systems, enabling smooth and adaptable motion. However, their compliant nature also makes them vulnerable to mechanical failures like punctures and tears, limiting practical deployment. To address this, we propose a puncture detection system for soft actuators using motion data from a single inertial measurement unit. Extracted features are used to train anomaly detectors for puncture detection and non-linear models to estimate severity. We also introduce a multi-chamber pneumatic soft bending actuator capable of diverse configurations via selective chamber inflation. Our algorithm identifies the punctured chamber and provides a severity score using a chamber perturbation scheme. Anomaly detectors are trained on normal operation data and detect damage through reconstruction errors, while severity is estimated by a separate model trained under slightly modified conditions. Finally, we demonstrate a failure recovery strategy to maintain actuation force post-failure. This approach enhances the reliability and safety of soft robotic systems through real-time, data-driven damage detection.