Abstract: Understanding video content requires reasoning at multiple levels of granularity, from identifying objects to interpreting their interactions and localizing when specific actions occur. This thesis studies three query-guided grounding tasks that answer where key objects are (object-level grounding), how they interact (relationship-level grounding), and when specific moments occur (moment-level grounding). For object-level grounding, we present QDETRv, a query-guided extension of the Detection Transformer for one-shot localization of unseen objects in videos, which combines query-context fusion, a memory module for temporal consistency, and unsupervised pretraining on synthetic object trajectories. We further propose the Temporal Object-Aware Vision Transformer (TOViT) for few-shot video object detection, which builds on a language-aligned open-set vision encoder and propagates high-confidence object features across frames. For relationship-level grounding, we introduce few-shot referring relationships in videos: given a (subject, predicate, object) query and a few support videos sharing the predicate, the entities are localized by optimizing a T-partite random field using a meta-learned relation network with query-conditioned translational embeddings, Global Semantic Aggregation, Local Localization Aggregation, and belief-propagation-based message passing. For moment-level grounding, we propose the Moment Alignment Transformer (MATR) for video-to-video moment retrieval, which uses dual-stage Dynamic Time Warping for pre- and post-fusion alignment, learnable queries for boundary prediction, and self-supervised pretraining with temporal augmentations; MATR also extends to text-to-video moment retrieval with performance comparable to, or better than, the state of the art. These contributions advance query-guided video understanding across spatial, relational, and temporal grounding.