Abstract: Density estimation with generative models is a common task in the physical sciences, for example in background estimation in particle physics. Existing machine learning techniques, however, lack methods to quantify uncertainties that can be propagated into a statistical test. That limits the validation of generative models to standard goodness-of-fit tests, in which the generative model is treated as exact (point-null hypothesis). But a model fitted to a finite training set is never exact, so if its uncertainties are neglected, any sufficiently powerful goodness-of-fit test will eventually reject it once the test set is large enough to resolve this estimation error. We propose SIGMA, an end-to-end framework combining density estimation with principled uncertainty quantification. We use Gaussian mixture models, for which uncertainties are tractable, and further construct a new goodness-of-fit test in which these uncertainties are profiled as nuisance parameters to account for the statistical error of the fit, promoting the conventional point-null test to a composite one. A rejection then signals genuine mismodeling rather than a test set large enough to resolve the error of the fit, provided the propagated uncertainties faithfully cover that error. We demonstrate the framework on a controlled two-dimensional toy model and on a collider physics benchmark modeling the QCD background process. With uncertainties included, the same model can be trusted on test sets up to an order of magnitude larger than the standard test allows. Our work thus provides a statistically grounded basis for a robust use of generative models in the physical sciences.