ophthalmology software developers

Abstract: Retinal fundus images frequently carry more than one disease, and public fundus datasets are heterogeneous and severely long-tailed. Clinical triage suggests a staged design, in which a screening gate, a disease-group router and group-specific classifiers operate in sequence, but it is unclear whether this hierarchy earns its complexity. We present a controlled comparison of three architectures on a unified 39-target label space built from RFMiD 1.0, RFMiD 2.0 and ODIR-5K (12,652 images): (i) a three-stage gated cascade of eight models, (ii) a flat model with 39 independent sigmoid outputs, and (iii) a label-correlation model that replaces the flat linear head with 39 learned label queries and a two-layer transformer decoder. All three share one Swin-V2-B backbone, one preprocessing pipeline and one training protocol, so differences are attributable to the architecture. Staging offers no consistent advantage: tracing every missed disease instance to the stage that lost it shows that the two coarse gates discard 34.2% of true instances while the fine-grained classifiers lose only 6.7%, and the gates' hard zeros depress the cascade's macro-AUC to 0.747. Label-correlation modeling gives the largest single gain, raising the detection rate from 0.621 to 0.682 (0.689 with test-time augmentation). Blending the flat and label-correlation models under four-view test-time augmentation is the best configuration on six of eight metrics (exact match 0.694, micro-F1 0.678, macro-F1 0.456, macro-AUC 0.972). On definition-matched class subsets it matches or exceeds four recent studies on macro- and micro-F1, most clearly on low-support pathologies. We also show that ensembling a gated cascade with continuous-output models is harmful, and that per-source negative sampling is needed to remove a dataset shortcut that otherwise yields a spurious AUC of 1.000.

Abstract: Recent advances in angiographic imaging have enabled longitudinal visualization of the microvasculature. Image processing pipelines based on vessel graphs are able to resolve subtle temporal changes at the level of individual blood vessels. However, current strategies for graph extraction, refinement, and matching are highly sensitive, with even minuscule differences in the underlying segmentation map resulting in substantially different vessel graphs. These artifacts severely inhibit the ability to accurately match sequential vessel graphs of the same subject over time. To address this problem, we propose a strategy that matches graphs before jointly refining them. Specifically, we perform an early matching after basic graph extraction before removing spurious bulges and merging junctions in both graphs using joint information. In experiments with complex retinal vessel graphs, we demonstrate that this strategy results in a higher matched area without graph fragmentation compared to separate or no refinement, respectively.

Abstract: Ultra-widefield (UWF) swept-source optical coherence tomography angiography (SS-OCTA) enables large-area retinal vascular imaging, yet vessel segmentation at this scale lacks dedicated public benchmarks and comprehensive evaluation for quantitative vascular analysis. We introduce WOIVES, to our knowledge the first publicly available UWF SS-OCTA vessel-segmentation dataset, comprising 206 eyes from 152 participants with a 24x20mm^2 field of view. WOIVES spans emmetropia to high myopia and provides soft probability vessel annotations. We further propose PG-Mamba, a visual state space model that enhances conventional directional scans with two complementary polar-coordinate scan orders. An auxiliary Dynamic FOV Gating module performs spatial modulation at the bottleneck. PG-Mamba outperformed seven competitive approaches on broad segmentation metrics under cross-validation. It achieved the lowest median absolute errors for vessel density, fractal dimension, and vessel length density. WOIVES is publicly available on Zenodo (DOI: 10.5281/zenodo.21904672), and the PG-Mamba code is available at https://github.com/syb1234567/PG-Mamba.