neurotechnology engineers

Abstract: Brain alignment of large language models (LLMs) offers a way to investigate representational similarities between LLMs and the human brain during language processing. While previous studies have mainly focused on passive language comprehension, little is known about such alignment during dialogue, in which speakers engage in both language production and comprehension. In this study, using fMRI data collected during dialogue, we examine brain alignment during language production and comprehension across LLM layers and brain regions. We assess its association with the intrinsic dimension (ID) of LLM representations and the contributions of several interpretable linguistic and communicative features. Our results reveal distinct patterns of brain alignment between production and comprehension, as well as strong associations with ID in brain regions associated with each processing mode. Furthermore, we show that the contributions of linguistic and communicative features also vary across processing modes, LLM layers, and brain regions.

Abstract: A fundamental challenge in cognitive science and neural computation is the binding problem. Compositional generalization can be achieved by factorizing representations into roles, the structural slots of a representation (e.g., serial position or syntactic function), and fillers, the contents occupying them (e.g., a phoneme or a word), which can be recombined freely to represent novel combinations. How neural systems implement role--filler binding, however, remains unknown. One of its simplest cases is phoneme sequencing, where phoneme identity (filler) must be bound to position (role) so that /gum/ and /mug/ are represented differently. A proposal from NLP, the `onion hypothesis' (Csordas et al., 2024), holds that the direction of the neural population state encodes token identity, while its magnitude encodes position. It was formulated for random token sequences; we extend it to natural language and test it in neural models and the human brain. We first evaluated it in an encoder-decoder trained to repeat English words, using representational geometry analyses and causal interventions. Magnitude alone proves incomplete: position is encoded by magnitude together with a systematic rotation of the state direction, a scheme we formalize as the `spiral hypothesis'. We then analyzed intracranial recordings from the auditory cortex of 20 participants listening to short sentences. Across superior temporal gyrus electrodes, the change in population response between consecutive phonemes decreases in magnitude as position advances, and its direction is aligned within consonants and within vowels but near orthogonal across the two classes, supporting the magnitude coding shared by both accounts. These results provide a geometric account of how neural systems bind phoneme identity to position, and show how neural-model hypotheses can yield testable predictions about human neural computation.

Abstract: Molecular neural interfaces that deliver and sense the same neurotransmitter must estimate endogenous release in the presence of their own chemical input. We study two exchanging regions with shared saturable uptake and concentration change measurements. Known delivery and exchange permit identification of apparent uptake at the driven region, but an unknown resting concentration difference leaves the source region's incremental uptake uncertain. We characterize all admissible source histories consistent with both ideal records and show how delivery and baseline information affect release classification. A dopamine-inspired example produces identical ideal concentration-change records for mean release-rate changes of -8.99 and +1.31 nanomolar per second. Stronger delivery changes whether all compatible sources imply suppression, with the true source held fixed. Under a Gaussian observation model, we bound discrimination based on chemical fluctuations. A baseline reference with an assumed standard deviation of 3.3 nanomolar reduces root-mean-square error from 10.41 to 1.21 nanomolar per second compared with an incorrect fixed baseline under exact gain calibration. Classification errors remain substantial with weak excitation, gain errors or responses near the category boundaries.

Abstract: Studying the alignment between the internal representations of vision models and the responses of the visual cortex to the same observed visual stimuli has enabled us to better understand human visual processing. However, studies so far have largely overlooked the fact that the human brain not only processes observed visual stimuli, but also predicts upcoming stimuli based on what has been observed. Accordingly, we hypothesize that internal representations for generating future video frames are better aligned with the predictive nature of human visual processing than representations of the observed video itself. To this end, we compare the alignment between human video-watching fMRI responses in the visual cortex and the internal representations from two types of video diffusion models, an autoregressive (AR) model and its non-AR base model. We first conduct a within-model analysis of the AR video diffusion model and show that the representations for future video generation align better with the visual cortex than the representations of the observed video. We then compare the internal representations of the AR model with those of its non-AR base model and again show that the representations for future video generation align better with the visual cortex than the representations for observed video reconstruction by the base model. Specifically, the alignment of observed video reconstruction is concentrated in lower-order visual cortex, whereas that of future video generation is concentrated in higher-order visual cortex. Finally, we show in a human behavioral experiment that humans prefer videos generated by amplifying the contributions of individual layers that align better with the visual cortex.

Abstract: Brain-AI alignment is often interpreted as a sign that model and brain perform similar computations. Whether the aligned units are causally involved in model computation is rarely checked. On an abstract pattern-completion task (AAABAAA $\rightarrow$ B), we compare LLM attention-head representations with human EEG and test how ablating those heads affects task performance. Alignment and causation dissociate: brain-aligned heads contribute to performance, but their removal is substantially less disruptive than removal of heads selected via attribution patching. We compare two head sets that prior interpretability work defines without reference to the brain: concept vectors (CVs), which represent abstract patterns across formats, and function vectors (FVs), selected for their contribution to correct-answer prediction. Brain alignment shows little association with FV scores, while its association with CV scores varies across models. Among brain-aligned heads, we find recurring attention profiles: one emphasizes distinctive elements (novelty heads), the other repeating elements (repetition heads). The novelty family tracks salience and attends to the same elements that humans look at, yet its removal is less damaging than random ablation on average. Repetition heads contribute modestly to performance and are associated with abstract-pattern representation (CVs). Across 17 models spanning 3B-72B parameters, FV-ranked removal is substantially more disruptive than brain-ranked removal. Brain alignment thus captures how the model reads the stimulus, and only faintly captures how it represents the pattern and solves the task.

Abstract: Large language models (LLMs) can predict human brain activity across a variety of brain regions during natural language comprehension. Typically, however, LLM-brain alignment is measured using one model for different regions of the brain, and then model performance is summarized across regions. This one-model-fits-all approach ignores the functional specialization of brain regions. In this study, we assess whether a model oriented toward a particular cognitive domain aligns better with the brain system dedicated to that domain. Through prompting and fine-tuning, we first build expert LLM variants for six domains: sensory, spatial, numerical, reasoning, social, and abstract processing. We then examine whether each expert best predicts activity in the brain region associated with the corresponding cognitive domain. Consistent with our hypotheses, each expert's representations align more closely with the brain system most associated with the matching domain than do other experts. This holds under both prompting and fine-tuning, across three base models and three fMRI datasets. In a series of control analyses, we show that this model-brain alignment is specific to cognitive domain interventions; non-cognitive and surface-level interventions do not result in comparable alignment. Specializing models shifts regional alignment while leaving aggregate prediction accuracy largely unchanged, suggesting that summarizing alignment across regions may obscure regional differences in performance for specific models.

Abstract: Perceived speech decoding based on non-invasive brain-computer interface (BCI) signals has been extensively studied in recent years. Research in this field primarily faces two challenges: extracting neural representations with rich spatiotemporal information and achieving cross-subject generalization. Although separate studies have proposed methods to cope with these issues, a unified approach that simultaneously tackles both challenges remains lacking. To fill this gap, we propose the Subject-Invariant Cross-Modal Perceived Speech Decoding (SICMD) method, which integrates functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG). We conduct comprehensive analyses of the fusion method, fusion position, encoder architecture, and model inputs. Our results demonstrate that the proposed method improves Top-1, Top-10, and Rankacc by more than 10.6%, 10.1%, and 1.7%, respectively, compared to baseline methods in cross-subject perceived speech decoding tasks, while reducing training costs by 88.8% and 60.5% compared to multi-subject and intra-subject decoding settings. Further visualization experiments also confirm the effectiveness of our approach.

Abstract: Deployment-oriented compression is attractive for resource-constrained brain--computer interfaces (BCIs), but whether it changes adversarial vulnerability remains unclear. On BCI Competition IV-2a, we compare 32-bit floating-point (FP32) EEGNet and ShallowConvNet models with global magnitude pruning and simulated INT8 post training quantization (PTQ) and quantization-aware training (QAT) across nine subjects and three seeds. Simulation provides differentiable quantize--dequantize models for white-box attacks and gradient analysis, while native TensorRT deployment is used for validation. Accuracy-preserving compression does not improve direct robustness: at $ε=0.005$, EEGNet PGD accuracy remains 22--24\% across FP32, 50\% pruning (P50), PTQ, and QAT. However, P50 reduces bidirectional transfer efficiency to 0.963/0.928 (FP32$\rightarrow$P50/P50$\rightarrow$FP32), versus 0.994/0.997 for PTQ; the same trend holds for ShallowConvNet. Gradient alignment shows a corresponding separation, while native PTQ agrees with simulated clean/adversarial predictions in 95--98\% of cases. These results show that direct robustness, adversarial transfer, and deployment efficiency are distinct properties of compressed EEG decoders.

Abstract: Brain-to-language decoding translates neural activity associated with language production, internal speech and perception into linguistic or expressive outputs. It offers a route to restoring communication after speech loss and a means of studying how the brain represents language. Advances in neural recording and representation learning have expanded the field from constrained recognition and acoustic reconstruction to text generation, streaming personalised speech and facial animation. This survey synthesises these developments across invasive and non-invasive measurements, drawing on a search without a lower year limit and source-led updates through September 2026. We connect Articulated, Inner and Perceived tasks to the neural populations they engage, the representations available to decoders and the outputs those representations can support. We examine model development, public resources and the evolution of evaluation, and compare published performance and communication costs within their reported protocols. The synthesis identifies complementary routes to progress: phonetic, acoustic and semantic targets preserve different aspects of a message; shared representations support reuse across recording conditions and tasks; and online communication increasingly depends on calibration, feedback and user control alongside decoding accuracy. Shared benchmarks enable algorithmic comparisons, while longitudinal studies reveal the demands of sustained use. We discuss these developments and their remaining limitations, then outline a prospective five-level trajectory from commands and language to meaning, scenarios and bidirectional cognitive exchange

Abstract: We propose the Platonic brain bridge hypothesis: omni models, which process video, audio and text jointly like the brain, converge on brain-like representations, and the correspondence is bidirectional. From model to brain, brain-likeness of seven omni models is stable across participants, and our encoding models on their internal hidden states rank first on the Algonauts 2025 out-of-distribution leaderboard. From brain to model, three contributions follow. Brain-MoE gives seven cortical networks one brain-pretrained expert each and raises held-out accuracy in all 15 model-benchmark pairs by 6.42 percentage points on average. Brain-AVQA builds questions from video clips labelled by the most responsive brain network; the real network-to-expert map exceeds shuffled maps in-domain on all three models. Brain-Scope uses sparse autoencoders to localize the correspondence to a small subset whose removal weakens brain prediction in all three bases tested. Human brain networks are therefore a usable architectural prior for omni models.