Abstract: This article introduces PeriodicCALM, an effective real-time anomaly detection framework designed for cyclostationary data streams. While classical cyclostationary processes feature periodically time-varying statistical properties, real-world signals often contain recurring impulsive components that conceal abnormal behavior. Existing real-time methods for struggle with these dynamics, frequently misinterpreting phase-dependent variability as non-cyclic anomalies and causing excessive false alarms. To address this, PeriodicCALM incorporates cycle-dependent variability to systematically ignore regular cyclic impulses while accurately isolating genuine anomalies. Operating in real time with continuous retraining capabilities, the method adapts dynamically to evolving signal characteristics. Comparative evaluations against the baseline CALM framework using simulated data demonstrate significant improvements in detection accuracy and training efficiency, alongside a reduction in prediction latency. Furthermore, the practical utility of PeriodicCALM is validated on real-world vibration signals collected from a compressor monitoring system.