mental health screening teams

Abstract: Web-enabled digital health services are expanding access to physiological monitoring and mental health screening. However, electroencephalography (EEG)-based major depressive disorder (MDD) detection remains challenging across heterogeneous data sources, where individual variability and acquisition differences may affect disease-related representations. In this work, we investigate the use of healthy normative references for EEG-based MDD detection. Specifically, structural and distributional reference models are independently trained using healthy control (HC) recordings to characterize departures from healthy EEG patterns. We develop two diagnostic approaches that incorporate normative deviations at different representation levels. Scalar-level Normative Deviation-guided Diagnosis (S-NDD) summarizes structural and distributional deviations into scalar scores and integrates them with deep EEG representations. Feature-level Normative Deviation-guided Diagnosis (F-NDD) retains dimension-wise residuals and combines them with deep EEG representations through attention-based aggregation and auxiliary supervision. We also employ target HC-assisted score calibration for cross-source evaluation without updating the trained models. Experiments on two public EEG datasets examine both approaches under subject-independent within-source and bidirectional cross-source settings. The results demonstrate the effectiveness of normative deviation-guided diagnosis across different evaluation settings.

Abstract: Natural language processing (NLP) models can detect depression-related language in text written near the time symptoms are measured, but whether pretrained transformers can predict depressive symptoms from text written twelve years earlier is largely untested. In the National Child Development Study, a British birth cohort, we predict probable depressive symptoms at age 23 from essays the same people wrote at age 11. Our baseline, a logistic regression on six childhood covariates, outperforms every text model that sees only the essay: seven fine-tuned transformers, a bag-of-words model, frozen embeddings and four zero-shot large language models. Its area under the receiver operating characteristic curve (AUC-ROC) is 0.737 against 0.670 for the best transformer on the primary seed, and no added text score detectably raises the baseline's AUC-ROC. None of the five domain-pretrained transformers detectably beats its general-domain control after Bonferroni correction. For long-horizon prediction, the baseline remains the model to beat.