mental health clinicians

Abstract: We investigate whether a 2D Convolutional Neural Network (CNN) trained on minimally preprocessed EEG signals can classify hypnotic susceptibility across distinct brain regions. Sixty-two male participants (32 Control, 30 Guided Imagery / Hipno group) underwent a 20-minute EEG recording using a 256-channel EGI cap. A sliding-window approach evaluates all 10-second windows within the recording for each of seven predefined brain regions (prefrontal, frontal, temporal, central, parietal, occipital, and facial), yielding up to 868 independently trained models. Initial screening with a segment-level 90/10 random split showed that five regions exceeded the 0.67 accuracy threshold, with the occipital region achieving the highest mean accuracy (0.721) across 90.3% of windows. Subject-independent evaluation via Leave-One-Subject-Out (LOSO) cross-validation, however, substantially revised this picture: occipital performance collapsed to near-chance (mean ACC 0.453, AUC 0.429), revealing that high random-split accuracy was driven by subject-specific EEG fingerprints rather than genuine group differences. In contrast, the frontal and prefrontal regions maintained above-chance LOSO accuracy (0.646 and 0.624, respectively), demonstrating genuine generalisability. These results underscore the necessity of subject-independent validation in EEG-based classification studies and highlight anterior cortical regions as more reliable neural markers of hypnotic susceptibility.

Abstract: Non-suicidal self-injury (NSSI) is prevalent among adolescents with depression, but the rapid brain-state dynamics linking social distress to maladaptive behavior remain unclear. We combine an experimental pain paradigm, electroencephalography (EEG) microstate analysis, and interpretable deep sequence modeling to investigate NSSI-related neurodynamics in 106 adolescents with depression, including 67 with NSSI (DN+) and 39 without NSSI (DN-), during social pain, physical pain, and resting-state conditions. A model integrating disease-specific, domain-adversarial, consistency, and contrastive learning captures higher-order dependencies in microstate sequences. Social pain yields the strongest NSSI discrimination, with 68.55% accuracy, outperforming the best baseline by 8.94% points. Model interpretation and conventional microstate analyses reveal weakened bidirectional transitions between MS3 and MS5 in DN+ adolescents during social pain. Source reconstruction associates MS3 with emotional/interoceptive processing and MS5 with action preparation, suggesting disrupted emotion-action coupling. Time-resolved analyses show greater early-to-middle action-state recruitment and later emotion-state recruitment in DN+ adolescents. In DN- adolescents, MS5-to-MS3 dynamics mediate associations between social-evaluation sensitivity and affective outcomes, whereas this mediation is absent in DN+; conversely, MS3-to-MS5 transitions are associated with greater negative affect in DN+. Together, these findings identify disrupted emotion-action coupling as a key neurodynamic mechanism underlying altered social pain processing in adolescents with NSSI, providing a mechanistically interpretable neural signature for objective identification of NSSI.

Abstract: We present BEACON-SP, an ontology-grounded Graph Retrieval-Augmented Generation (GraphRAG) framework for clinician-facing decision support in behavioral health settings such as suicide prevention, where effective assessment requires integrating heterogeneous clinical, behavioral, social, and temporal evidence. BEACON-SP combines patient knowledge graphs with ontology-guided retrieval to support multi-hop reasoning across diagnoses, medications, risk and protective factors, life events, and temporal relationships. The framework is enabled by a comprehensive suicide prevention ontology that integrates the Three-Step Theory, the Integrated Motivational-Volitional Model, and the Suicide Social Determinants of Health Ontology into a unified representation of patient risk factors. We construct ontology-grounded patient knowledge graphs and evaluate BEACON-SP for clinician-facing question answering. Compared with a vector-based retrieval-augmented generation (RAG) baseline on a 1,500-query benchmark spanning 15 clinical categories and 100 patients, BEACON-SP improves completeness, clinical relevance, and evidence grounding under a corrected comparative evaluation protocol, with a small gain on factual accuracy. In paired criterion-level comparisons, GraphRAG is preferred in 76.4% of cases. These results demonstrate the potential of ontology-guided GraphRAG to provide structured, contextualized patient evidence for clinical decision support.

Abstract: Cognitive behavioral therapy (CBT) is an evidence-based first-line treatment for depression, yet its scale is constrained by the time clinicians spend on pre-session preparation, post-session documentation, and longitudinal cognitive-pathology tracking. We present a clinician-facing AI decision-support system that combines a multi-agent CBT framework (MACBT) with a CBT-specific longitudinal memory module (CD Memory). MACBT encodes the five-stage CBT workflow (assessment, Socratic questioning, cognitive restructuring, behavioral experiments, and treatment monitoring) into five collaborative agents. CD Memory tracks cognitive-distortion type, frequency, severity, and restructuring efficacy across sessions to generate pre-session pathology reports and intervention-priority recommendations. We construct a Chinese CBT dialogue corpus via dual-role large language model simulation and train a Qwen3-14B backbone with supervised fine-tuning and direct preference optimization. Evaluation with GPT-4 judges shows MACBT outperforms MeChat, SoulChat, PsyChat, and CPsyCounX in professionalism (2.62) and clinical authenticity (2.25). The full memory-augmented system further improves session quality by 12.6% and achieves a longitudinal mean of 2.29 on cross-session continuity, intervention progression, and personalization.

Abstract: Importance: Reports have raised concerns that AI chatbots may validate or elaborate delusional beliefs, respond inappropriately to suicidal ideation, and contribute to mental health harms, but real-world data on reported harms remain limited. Objective: To characterize psychopathological features, chatbot behaviors, timing, and outcomes in first- and second-hand accounts of mental health harm linked with AI chatbot use. Design: Cross-sectional secondary analysis of deidentified online survey responses gathered between August 7, 2025, and February 2, 2026. Main Outcomes and Measures: The primary quantitative outcome was the presence of delusional beliefs, coded by paired raters with relevant clinical experience. Additional variables included reason for chatbot use, current episode features, delusional content, chatbot validation of beliefs, harms, social and occupational consequences, healthcare use, and timing. Results: 95 first-hand and 90 second-hand accounts were analyzed. Median age was 35.0 (IQR 27.0 - 45.0). Raters coded descriptions consistent with delusional beliefs in 102 reports (55.1%), with chatbot validation of beliefs in 50/102 (49.0%). Common outcomes included isolation, relationship breakdown, hospital admission, job loss, and financial loss. Four second-hand reports described death by suicide. Conclusions: In this self-selected convenience sample, AI-chatbot-associated harms were frequently described in relation to delusional beliefs, perceived chatbot validation, intensive use, and substantial social, occupational, and clinical consequences. Because reports were retrospective, unverified, and collected from individuals seeking to report harm, our findings should be interpreted as preliminary signal detection rather than as suggesting prevalence or providing evidence of causality. Prospective surveillance and trajectory-based safety evaluations are needed.