medical imaging analysts

Abstract: Multimodal prediction relies on diverse forms of evidence: information repeated across modalities, cues specific to a single source, and complex cross-modal dependencies that emerge only when inputs are considered together. While recent methods promote richer interactions, they lack a principled way to isolate these target-relative contributions within learned continuous representations. We introduce a framework that applies contrastive or masked objectives at intermediate layers, coupled with source-wise invertible normalizing flows and a supervised, low-rank latent variable model. This architecture explicitly factorizes the joint distribution into shared task-relevant variation, modality-specific predictive variation, and task-irrelevant dependence. Drawing connections to prior multimodal learning assumptions, our approach evaluates how modalities independently and jointly contribute to the target. Ultimately, this framework unites intermediate representation learning with structured likelihood-based guidance, offering a practical latent-variable lens for characterizing continuous multimodal interactions. Empirically, we demonstrate the effectiveness of our approach across diverse multimodal benchmarks, showing robust improvements in predictive performance.

Abstract: Adapting general-purpose multimodal large language models (MLLMs) to specialized domains requires learning domain-specific decision criteria, which often hinge on subtle visual distinctions between otherwise plausible answers. Rationale augmentation aims to expose such evidence through additional observations or inter-sample comparisons, yet a visually valid cue is not necessarily decision-relevant: it may describe how samples differ without changing the model's relative preference between competing answers. We therefore introduce BIRD, a self-improving Boundary-Informed Rationale Distillation framework that uses model-specific confusions to locate unresolved local decision boundaries and distills the evidence that resolves these confusions into rationales. For each sample, BIRD retrieves candidate neighbors from the target MLLM's own representation space and selects the most confusable one according to its answer preferences. It then generates answer-blind candidate evidence from their visual differences and functionally verifies which evidence most effectively strengthens the model's preference for the correct answer while avoiding inappropriate transfer across the pair. The verified evidence is then distilled into a single-sample rationale for standard supervised fine-tuning. Experiments on medical and chart VQA show that BIRD outperforms competing rationale-augmentation methods across two target MLLMs, while further analyses demonstrate clearer separation of confusable answers and stronger gains from model-matched supervision.

Abstract: Effective-connectivity estimation from brain signals often relies on Gaussian residual modeling, which enables tractable estimation but can discard informative distributional structure and distort inferred directed interactions when empirical residuals are non-Gaussian. We show across multiple modalities, species, and experimental conditions that both brain signals and fitted channel residuals frequently deviate from Gaussianity. We therefore introduce a distribution-aware, information-theoretic measure of effective connectivity based on channel capacity under general residual distributions. To estimate the resulting capacity from empirical, potentially non-Gaussian residuals, we develop a dual-flow min-max estimator based on normalizing flows, in which a generator searches over admissible input distributions under a power constraint while an observer estimates output entropy. We provide a theoretical characterization of the estimator, showing that the observer objective recovers differential entropy up to a KL approximation term, that the formulation reduces to classical Gaussian capacity as a special case, and that residual entropy can alter achievable information rates beyond variance; game-gap and error analyses further characterize optimization and approximation sources. In brain-like simulations with known directed connectivity, Dual-flow achieves the highest AUROC and AUPRC across ten conditions spanning diverse network topologies, hidden drivers, feedback, and heterogeneous hemodynamics, compared with Gaussian capacity, Granger causality, VAR-LiNGAM, and GIMME. Applied to multimodal brain signals, the method reveals time- and condition-resolved directed interactions consistent with known neurobiological circuitry. Together, these results establish a principled distribution-aware framework for effective-connectivity estimation beyond Gaussian residual modeling.

Abstract: Brain-age prediction from resting-state fMRI provides a quantitative framework for characterizing age-related changes in spontaneous brain dynamics and for identifying functional signatures. Existing studies have linked fractal and multifractal scaling to age and examined the reliability of individual features. However, prediction repeatability depends on how features fluctuate jointly and how a predictor combines them, which feature-wise reliability assessments do not capture. To address this problem, we propose Repeat-informed Multifractal Curve Regression (RMCR), a structured framework for learning stable age-predictive patterns from multifractal curves. By jointly modeling curve structure and repeat-scan variability, RMCR learns predictive combinations of fluctuation orders that target both accuracy and within-subject consistency. Relative to a matched run-level ridge baseline, RMCR reduces single-run MAE by 6.1% on HCP-A and 7.9% on an external Cam-CAN cohort, and within-visit repeat absolute difference by 18.5% on HCP-A, using a single scan at inference.

Abstract: Spatial transcriptomics (ST) measures gene expression in tissue context, but dense capture grids can be costly and may repeatedly sample morphologically similar regions. Most active learning strategies were developed for categorical labels and independent samples. We conduct a retrospective pool-based benchmark of active learning versus uniform Random sampling for ST, where expression vectors are high-dimensional and continuous and candidates are spatially correlated. Using two fully profiled public ST cohorts, we mask candidate expression vectors and simulate multi-round selection with uncertainty-based Monte Carlo dropout (MC-dropout) and temporal output discrepancy (TOD), and diversity-based CoreSet and TypiClust-inspired selection. We compare 160 completed configurations at 5%, 10%, 30%, and 50% of the fold-wide training spot pool under patient-level cross-validation, with a separate full-label reference. Within each budget, strategies share the selection schedule, morphology-to-expression predictor, and optimization protocol. We assess mean per-gene within-slide Pearson correlation coefficient (PCC), expression-cluster agreement, and Moran's I fidelity. On HER2-positive breast cancer, pooled mean PCC differences from Random across the four active strategies were -0.0176, -0.0117, +0.0056, and +0.0057 at 5%, 10%, 30%, and 50%, respectively. On cutaneous squamous cell carcinoma (cSCC), three strategies were below Random at 5%, and all four were below Random at 10%. On HER2-positive breast cancer, CoreSet and MC-dropout had lower PCC but higher expression-cluster agreement than Random at the two smallest budgets; this pattern did not reproduce on cSCC. Under the reported fixed training horizons, the evaluated active strategies do not consistently improve on Random at small budgets, and rankings depend on the evaluation measure.

Abstract: Traditional unsupervised anomaly detection (UAD) methods are designed to flag or localise deviations from a normative distribution, ignoring the underlying generative mechanisms of the anomalies. Yet the nature of an anomaly is often as important as its presence. We reformulate UAD as a Bayesian inverse problem, in which the objective is to infer the most probable corruption responsible for each observation. Our framework yields a probabilistic anomaly score as the energy of the inferred corruption parameters, and serves as a principled recipe for developing new UAD algorithms. We derive several existing methods as instances of the general framework, each corresponding to the same energy score under different modelling choices. Experimentally, we study the framework's components in a controlled setting, and improve object-class AUROC on the MVTec AD dataset by 2.3% by adapting the underlying corruption model. Finally, we validate the framework on a brain MRI benchmark, achieving strong detection performance while producing estimates of pathology intensity, bias, and geometry. Code is available at https://github.com/jgmyles/inverse-uad.

Abstract: This paper proposes a Retrieval-Augmented Generation (RAG) framework for scientific image quality assessment, designed to simultaneously address both the understanding track (SIQA-U) and the scoring track (SIQA-S) of the SIQA challenge. We construct a multimodal index that integrates textual semantics with fine-grained visual features, and develop a multi-route retrieval and fusion mechanism to provide large language models with highly relevant reference cases, thereby enhancing their capability to evaluate complex scientific images. Experimental results demonstrate that the proposed framework effectively aligns with the judgment criteria of human experts. Ultimately, our method achieves 1st place in the SIQA-U track of the SIQA challenge at the ICME 2026 Grand Challenges.

Abstract: Time-warping estimation is a fundamental problem in signal processing with applications in bioacoustics, radar, and biomedical analysis. This paper introduces a Time-Warping Estimation Trainable (TWET) model for estimating timewarping functions from a single observation. The proposed approach formulates time-warping estimation as a stationarization problem in the wavelet domain and leverages a hierarchical dilated convolutional architecture to estimate the time-warping functions. A differentiable stationarity criterion is introduced for end-to-end optimization. TWET is compared with existing approaches. Experimental results show improved deformation reconstruction accuracy together with significantly reduced computation time, making the framework compatible with low-latency applications.

Abstract: Zero-shot anomaly detection aims to localize anomalies without target-domain samples. Existing CLIP-based methods suffer from coarse anomaly maps and limited semantic prompts. We propose PSMP-CLIP, integrating patch-prompt SAM2 segmentation (PPSS) and multi-semantic guided prompt regularization (MSGPR). PPSS samples prompts directly from intermediate patch features, avoiding threshold drift and guiding SAM2 to produce precise masks. MSGPR uses multiple learnable prompts constrained by semantic anchors to preserve generalization. Experiments on 14 datasets show highly competitive performance, achieving the best pixel-level AUROC on MVTec AD, BTAD, DTD-Synthetic, CVC-ClinicDB, TN3K, Endo, and Kvasir.

Abstract: Astronomical spectra encode rich physical information, but drawing scientific conclusions from spectral features typically requires expert interpretation. This paper presents AstroSpecLM, a spectrum-language model that connects one-dimensional DESI spectra with Qwen3-4B to answer questions and provide explanations grounded in spectral evidence. Instead of generating question-answer pairs directly from templates or raw catalog fields, we first distill each spectrum into a compact set of catalog- and spectrum-derived facts, then use these facts as references to generate instruction-following conversations. The resulting model is competitive with specialist supervised baselines on classification and redshift estimation, while additionally producing natural-language explanations that reference specific spectral features. Our results indicate that grounding a language model in one-dimensional scientific spectra is feasible, and that fact-mediated instruction data yields a model capable of both prediction and explanation.