medical device developers

Abstract: Perceived speech decoding based on non-invasive brain-computer interface (BCI) signals has been extensively studied in recent years. Research in this field primarily faces two challenges: extracting neural representations with rich spatiotemporal information and achieving cross-subject generalization. Although separate studies have proposed methods to cope with these issues, a unified approach that simultaneously tackles both challenges remains lacking. To fill this gap, we propose the Subject-Invariant Cross-Modal Perceived Speech Decoding (SICMD) method, which integrates functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG). We conduct comprehensive analyses of the fusion method, fusion position, encoder architecture, and model inputs. Our results demonstrate that the proposed method improves Top-1, Top-10, and Rankacc by more than 10.6%, 10.1%, and 1.7%, respectively, compared to baseline methods in cross-subject perceived speech decoding tasks, while reducing training costs by 88.8% and 60.5% compared to multi-subject and intra-subject decoding settings. Further visualization experiments also confirm the effectiveness of our approach.

Abstract: Understanding the neurobiological mechanisms underlying self-referential cognition and baseline self-consciousness remains a fundamental challenge in computational neuroscience. In this work, we propose a large-scale computational model incorporating a 10,000-neuron spiking neural network (SNN) based on Izhikevich dynamics. The network is structured into two interacting subsystems: a sensory processing layer (5,000 regular-spiking cortical neurons) and an endogenous Default Mode Network (DMN) pacemaker subsystem (5,000 intrinsically bursting neurons). The DMN layer is modulated by continuous tonic currents reflecting ascending brainstem neuromodulation, maintaining intrinsic, autonomous bioelectric rhythms independent of external sensory input. To represent top-down cognitive modulation, synaptic weights are hierarchically structured such that DMN-to-network projections exceed sensory-level connections. Through numerical simulations using a modified two-step Euler integration scheme, we demonstrate how endogenous pacemaker activity interacts with transient external sensory perturbations, providing an elementary mathematical framework for the emergence of a persistent, self-sustaining neural representation of "Self".

Abstract: Continuum manipulators provide dexterous motion in confined spaces, but structural compliance, hysteresis, and load-dependent deformation leave residual position and orientation errors that can undermine reliable contact with rigid grippers. To address this limitation, this paper presents a lightweight support-enhanced granular-jamming gripper tailored to a continuum manipulator. The gripper maintains compliance before jamming while establishing a direct load path to the continuum manipulator tip after jamming. To improve its grasping performance, we systematically designed membrane materials, particles, filling ratios, and the internal support structure, and further identify geometry-dependent grasp boundaries with respect to contact offset and object shape. Building on these results, we construct a physical manipulation system integrating the continuum manipulator, granular-jamming gripper, visual feedback, tendon actuation, and pneumatic control. We then train a reinforcement-learning-based reaching controller in a randomized simulation and deploy it on the physical system, demonstrating how positioning control and contact level mechanical adaptation can complement each other in a modular grasp-and-release task. By introducing an adaptive structure that relaxes the need for highly accurate modeling and positioning control, this work explores a design paradigm that integrates physical and embodied intelligence.

Abstract: The SYNTAX score is an established tool for assessing coronary artery disease and guiding revascularization treatment decisions. However, its manual estimation from coronary angiography videos by clinical experts is time-consuming and subject to inter-reader variability. While machine learning has shown promise in automating this process, prior work has primarily focused on lesion detection, characterization, or binary disease classification, leaving direct SYNTAX score prediction relatively unexplored. We propose SynSeq, a video-based method for direct SYNTAX score prediction. It combines targeted preprocessing with a tailored training strategy using a zero-inflation-aware loss and linear target scaling. Evaluated on the public CardioSyntax dataset, SynSeq significantly outperforms previous state-of-the-art methods, improving $R^2$ by 0.55, reducing prediction bias by 93.1% and achieving more consistent performance across annotations from three independent expert graders. In addition, SynSeq achieves a weighted $F_1$-score of 0.80 for revascularization treatment recommendations, slightly below inter-expert agreement. These results demonstrate the potential of SynSeq to provide consistent, automated SYNTAX score assessment and reliable decision support for coronary revascularization planning.

Abstract: Controlling the shape of a continuum soft robot typically requires an accurate dynamic model and actuation of all degrees of freedom. We show that regulating only the actuated coordinates, through collocated shape control, achieves provably stable convergence of those coordinates and, under an explicit compatibility condition, of the entire robot shape. While collocated control is a cornerstone of high-performance motion control in rigid robotics, extending this formulation to continuum soft robots has remained challenging due to the complexity of their dynamics. We present the first general framework for collocated control of continuum soft robots and derive a unified family of controllers, including PD, PID, PsatID, and their counterparts with compensation and cancellation components. The framework unifies existing approaches while introducing new controller designs. In particular, we develop three classes of PD and PID like regulators with local, semi-global, and global stability guarantees, and provide rigorous convergence analyses for each. Extensive experimental validation demonstrates the effectiveness of the proposed methods across different model discretizations and controller parameters. The resulting framework provides practical design guidelines for selecting and implementing controllers with known stability guarantees, without requiring a complete dynamic model of the robot

Abstract: Purposes: To characterize longitudinal retinal vascular changes in myopic children treated with orthokeratology (OK) or multifocal defocus lenses (Defocus) and to examine their association with axial elongation. Methods: In this retrospective cohort study, 43 myopic children underwent comprehensive clinical examination and fundus photography at baseline, 12 months, and 24 months. Axial length (AL) and spherical equivalent refraction (SER) were recorded at baseline, 6, 12, and 24 months. An automated segmentation model extracted vascular parameters, main vessel angle (MA), branching angle (BA), bifurcation edge angle (BEA), crossover point (COP), and terminal vessel count (TVC). Repeated-measures ANOVA assessed temporal changes. Pearson or Spearman correlations evaluated associations between AL and vascular metrics. Results: Over 24 months, the OK group exhibited significantly slower axial elongation than the Defocus group (0.214 mm and 0.522 mm, p < 0.01). In the OK group, MA and BA decreased modestly, BEA in arteries declined gradually, but COP and TVC remained relatively stable. The Defocus group demonstrated more pronounced decreases in MA and BA, an increase in BEA, and significant reductions in COP and TVC (p < 0.05). Correlation analysis revealed stronger associations between AL and vascular parameters, especially COP and TVC, in the Defocus group at all time points, whereas only BA and BEA correlated with AL in the OK group. Conclusions: OK lenses mitigate axial elongation and induce milder retinal vascular remodeling compared to Defocus lenses. Distinct temporal patterns of vascular metrics changes were observed between the two interventions, and correlate differentially with axial growth.

Abstract: Surgical videos are a primary resource for teaching trainees anatomy, tool usage, and procedural skills. Yet learning from them at scale requires systems that understand surgical scenes. Existing approaches fall short: vision-language models lack fine-grained domain reasoning, task-specific models do not generalize, and prior scene graphs omit clinically meaningful detail. We present SurgGraph, a training-free pipeline that generates quantitative scene graphs from surgical videos. Operating on segmentation masks and depth maps, SurgGraph encodes each clinically meaningful relation (attachment, occlusion, separation, tool actions) as a <subject, verb, object, value> tuple whose numeric value quantifies the relation's extent over time. Technical evaluations show more precise scene understanding than state-of-the-art surgical VLM baselines. We then build SurgGraphQA, a proof-of-concept learning application that retrieves meaningful and boundary-case exemplars and generates visual explanations and feedback. A study with 17 medical students and 2 resident surgeons shows significant learning gains, demonstrating its educational value.

Abstract: Autonomous endoscopic navigation requires the policy model to predict actions from texture-poor monocular observations, make safe control decisions, and retain evidence of lesions after they leave the field of view. Existing vision-language-action (VLA) models primarily rely on visual appearance and short-term context, limiting geometric grounding and episode-level reporting. We introduce StenoVLA-3D, a 3D-aware VLA framework for navigating through stenotic regions. We integrate point-maps into the Cosmos-Reason 2 backbone through learned geometry-gated fusion, and also propose a temporal state branch to model traversal progress. Our reasoning-and-action backbone predicts grounded reasoning with actions, while dedicated heads estimate stenosis shape and generate the final lesion report. We further introduce EndoCausal, an episode-level dataset with lesion annotations, actions, and temporally grounded reasoning. On 40 held-out recorded test episodes, StenoVLA-3D reaches 95.2\% semantic accuracy and 83.4\% action accuracy. On the physical 3-DoF endoscope, it attains 88.9\% and 77.8\% task success in esophageal and colonic phantoms (36 trials each), substantially outperforming the evaluated baselines.

Abstract: Deploying efficient neural networks is essential in resource-constrained environments, yet compact models often sacrifice interpretability - a critical in safety-critical domains such as autonomous driving and medicine. This study investigates whether Knowledge Distillation transfers the spatial feature attribution of a large teacher network to a compact student. To assess the influence of the KD scheme on interpretability, we distill a ResNet-152 teacher into a ResNet-34 student on ImageNet-1K across five configurations by systematically varying the distillation temperature and soft-label loss weight. Models are evaluated on top-1 accuracy, along with two interpretability metrics: Relevance Mass Accuracy and Relevance Rank Accuracy. These metrics are computed via Grad-CAM heatmaps benchmarked against ground-truth object masks. Our results show that top-1 accuracy ranges from 71.6% to 74.0%. For Grad-CAM, RMA ranges from 7.7% to 9.7% and RRA from 7.3% to 10.1%; for Guided Grad-CAM, RMA ranges from 16.1% to 18.6% and RRA from 15.9% to 21.5%. Interpretability proves far more sensitive to the soft-label weight than to the temperature: keeping the student anchored to hard labels preserves both accuracy and coarse localization, whereas weighting the teacher heavily degrades both. Fine-grained attribution, however, fell below the undistilled baseline in every configuration tested, indicating that logit distillation transmits where a model attends more readily than the pixel-level structure of that attention. We evaluate 12 cross-architecture combinations of convolutional and transformer-based models, revealing that the inheritance of fine-grained spatial reasoning is fundamentally bottlenecked by the student's intrinsic structural biases. To our knowledge, this is the first application of this interpretability-aware evaluation framework - previously used for neural network pruning - to KD.

Abstract: Brain lesion segmentation is a fundamental task in medical image analysis, playing a critical role in diagnosis, treatment planning, and longitudinal disease monitoring. Yet existing models still struggle to meet the demands of real clinical use, where deployments contain data distribution shifts, arising from differences in scanner hardware, imaging protocol (varying MRI modality sets), and new pathologies. We present BrainIAC (Brain lesion Interactive Adaptive Continuously learning segmentation), a unified framework that integrates (i) a multi-modal backbone network trained to segment multiple types of brain lesions and handle heterogeneous sets of modalities via zero-filling and random modality dropping; (ii) 3D interactive segmentation with bounding-box and click prompts that preserves fully automatic prediction when no prompt is given; and (iii) an online adaptation mechanism combining Mid-Interaction adaptation and Post-Interaction adaptation, supervised by the network's own predictions as pseudo labels and guided by an extra Click-Centered Gaussian loss. To our knowledge, this is one of the first 3D online adaptation methods for interactive segmentation, and the first to combine handling of heterogeneous modality sets with online adaptation. Experiments across seven brain MRI datasets demonstrate that the proposed components provide complementary and synergistic benefits. The method consistently outperforms existing approaches and generalizes well across heterogeneous imaging modalities, including those unseen during training, as well as previously unseen brain pathology types. The code and a 3D Slicer plug-in will be released at https://github.com/WenTXuL/BrainIAC upon publication.

Abstract: Purpose: A vertebra at the lumbosacral junction is named by counting caudally from C2 on whole-spine imaging, but a lumbar case is planned on lumbar-only imaging (T12 to S1), without C2. Abdominopelvic CT holds that span plus the lowest ribs and pelvis. Where a lumbosacral transitional vertebra (LSTV) alters the count, the local anatomy is ambiguous: four rib-free vertebrae may be an L1 with a lumbar rib or an L5 assimilated to the sacrum, and six may be a sixth lumbar vertebra, a T12 with aplastic ribs, or a lumbarized S1. CTSpinoPelvic1K asks whether local morphology resolves it without the count. CTSpine1K's vertebrae and CTPelvic1K's pelvis covered these patients but were never joined; this release joins them on one series and adds the bones neither had. It provides 802 CT records with per-level ribs and femora, levels anchored on the lowest rib-bearing vertebra and S1, and classes for L6, T13, a separate S1 and lumbar ribs, so anomalies are recorded as such. Acquisition and Validation Methods: Records pair CTSpine1K and CTPelvic1K labels on each patient's bone-richest series under a VerSe-native scheme. Validation covered geometric invariants (802/802 pass), rib-vertebra incidence across 5,749 ribs (0.035% offset), and spinopelvic measures matching published values. Data Format and Usage Notes: NIfTI image/label pairs with patient-grouped LSTV-stratified five-fold splits and a loader; archived at https://doi.org/10.5281/zenodo.22139642. Potential Applications: Classifying a vertebra from local features; updating cadaveric morphometry; spinopelvic assessment; opportunistic screening; and, absent a public preoperative lumbar cohort, surgical planning research (377 records prone). Limitations: thoracic ground truth is field-of-view limited; postural angles supine; no held-out test set; ribs are triaged-review pseudolabels; Castellvi grades two-reader consensus on 33 records.

Abstract: Lightweight and slim manipulators enable safe operation in human living environments. Proximal actuation using remote transmission mechanisms, such as wire-driven or Bowden cables, effectively reduces inertia and arm size by relocating motors near the base and transmitting torque to distal joints. Existing approaches either increase mass through additional components, such as pulleys for direction changes, or suffer from reduced transmission efficiency due to friction losses. Flexible shaft transmission avoids both mass increase and excessive friction losses, but faces increasing angular transmission error due to helical buckling caused by slack generated at joint bending. To address this problem, we propose SHAFT: a Slack-compensating, Helical-buckling-Attenuating Flexible- shaft Transmission mechanism. This mechanism compensates for slack through a proximal tensioner, improving the angular transmission error and efficiency of flexible shaft transmission without increasing the moving mass of the arm section. In a transmission path containing four 90-degree bends, the proposed mechanism demonstrated approximately 30% higher efficiency and approximately 65% lower angular transmission error compared to a flexible shaft transmission without a tensioner. Using this mechanism, we fabricated a 6-Degree-of-Freedom (DoF) arm with a 1-DoF gripper manipulator consisting of a rotary module housing motors with a tensioner, and a 280 g weight for the arm module. The proposed manipulator represents a novel remote actuation system for achieving lightweight construction with high efficiency, contributing to the acceleration of safe robot deployment in human environments.

Abstract: We study binary classification with abstention under separate class-conditional error constraints, with the objective of minimizing abstention while keeping both errors below prescribed thresholds. We characterize the distribution-free minimax rate of excess abstention risk, up to logarithmic factors, in terms of the complexity of the hypothesis class and the sample size. To make the framework amenable to computation with models such as neural networks, we introduce surrogate-loss formulations and derive finite-sample guarantees for excess surrogate ambiguity risk. We formulate the resulting learning task as a constrained optimization problem and characterize its computational complexity in the convex setting. Finally, we evaluate our approach on various datasets and compare its performance with a competing method for this problem.

Abstract: This paper presents a novel framework integrating Bayesian physiological modeling with optimal control strategies to achieve uncertainty-aware, personalized hemodynamic regulation during fluid resuscitation. An uncertainty-aware variational autoencoder state-space model (UVAE-SSM) was first developed to capture the dynamical relationship between mean arterial pressure (MAP) and fluid infusion using limited data, while explicitly modeling aleatoric uncertainty (i.e., randomness in the measurements, such as sensor noise). Then, a Bayesian nonlinear state-space model (BNSSM) was developed by utilizing Bayesian neural networks (BNNs) to capture epistemic uncertainty arising from physiological and patient-specific variability, enabling the creation of a virtual patient generator (VPG). Building on this uncertainty-aware modeling framework, a stochastic radial basis function model predictive control (sRBF-MPC) algorithm was designed to track the MAP target while satisfying physiological constraints. Finally, an online fine-tuning algorithm was developed to adapt the nominal UVAE-SSM using streaming VPG data, enabling progressive personalization during closed-loop therapy. Simulation results across unseen animal subjects and an independent human clinical dataset demonstrated the strong predictive accuracy and cross-population generalizability of the UVAE-SSM and BNSSM models. Closed-loop evaluations confirmed that the proposed sRBF-MPC framework achieved stable MAP regulation while providing better risk-aware control compared to quadratic MPC (Q-MPC) and stochastic quadratic MPC (sQ-MPC). Overall, the proposed framework accounts for inter- and intra-patient variability through online model adaptation, offering a promising step toward uncertainty-aware, personalized hemodynamic modeling and control in critical care.

Abstract: Deep neural architectures are widely used for signal processing in automated pain assessment systems. However, architecture design has remained largely a manual task despite the potential efficiency benefits of Neural Architecture Search (NAS). Embedding NAS in a Leave-One-Subject-Out (LOSO) evaluation is computationally demanding because a fully nested implementation requires $N$ independent architecture searches and, assuming approximately linear training cost, scales as $\mathcal{O}(N^2)$. We propose a block-based, leakage-controlled approach that shares NAS runs between subjects, reducing the number of searches from $N$ to $B$, where $B \ll N$, dubbed PainNAS. On the BioVid Heat Pain dataset, PainNAS yields comparable subject-level accuracy with substantially fewer parameters and FLOPs.

Abstract: This work proposes a real-time 6 Degree-of-Freedom (6 DoF) tracking algorithm for monocular laparoscopic surgery. It provides alignment between intra-operative video and pre-operative data (e.g., CT). The 6 DoF tracking offers a solution for accurately locating the internal anatomy of the target organ despite the lack of tactile feedback and transparency. The ORB-SLAM2 framework is adopted and modified for prior-based 3D tracking with four major modifications. First, the primitive 3D shape is used for fast initialization of the ORB-SLAM2 monocular mode. Second, a pseudo-segmentation strategy is employed to separate the target organ from the background for tracking. Third, the 3D shape is incorporated as a geometric prior in its pose graph optimization. Fourth, the Multi-Scale Retinex with Chromaticity Preservation (MSRCP) algorithm is leveraged and modified for image enhancement in challenging illumination scenarios. In-vivo and ex-vivo experiments validate that LapaTrack-3D provides robust 3D tracking and effectively handles typical challenges such as poor illumination, fast motion, out-of-field-of-view scenarios, partial visibility, and ``organ-background'' relative motion. LapaTrack-3D achieves a processing rate of 13 Hz for 1280*720 pixel video.

Abstract: We propose a new probabilistic model for general-purpose medical image registration that builds upon the mutual information registration criterion. It centers around a spatial interpolation technique that assumes latent voxel-wise correspondences between the images being registered. By exploiting these latent variables, we derive dedicated optimization and MCMC sampling techniques that only involve closed-form iterative updates. When applied to nonlinear registration, an efficient demons-like optimization algorithm is obtained that shows robust out-of-the-box performance across a variety of monomodal and multimodal registration tasks. We also demonstrate a corresponding sampler that can quantify, for the first time, uncertainty in multimodal registration scenarios with very high-dimensional 3D deformations. Our code, which we call BINDER (Bayesian INference for DEformable Registration), is freely available at https://github.com/ste93ste/BINDER.

Abstract: The inverse problem of reconstructing optical properties, specifically absorption and scattering coefficients, in layered biological media from time-domain reflectance measurements remains a significant challenge for traditional analytical models. Inverse solvers based on the diffusion equation often struggle with structural heterogeneity, frequently yielding poor accuracy for superficial absorption and deep-layers scattering. In this work, we propose a machine learning framework as an alternative approach to reconstruct the optical properties of a bilayered medium, benchmarking its efficiency and accuracy against model-based algorithms. To overcome the intrinsic approximations of diffusion theory and inverse reconstruction, we generated a robust synthetic dataset of forward DTOF using exact Monte Carlo simulations at multiple source-detector distances. A machine learning pipeline was then trained on this dataset and validated against state-of-the-art model-based reconstruction methods. Besides the significant reconstruction speed-up, the machine learning approach achieves higher accuracy than model-based inverse solvers, further providing an estimate of the parameter space dimensionality without requiring any a priori information about the number of layers in the investigated geometry. Further enhancements in the reconstruction accuracy can be expected in future extensions of this work, by training the pipeline over multiple DTOF curves from the same medium, in a joint multi-distance reconstruction approach.

Abstract: Needle-tip localization in ultrasound remains challenging because the needle may appear weak, discontinuous, or partially invisible, while imaging artifacts and anatomical structures can produce similar responses. To address this problem, we propose STUNet-Fusion, a spatiotemporal framework for needle-tip localization in ultrasound videos. The proposed method formulates the input as a tri-channel spatio-temporal fusion tensor, comprising grayscale appearance, grid-based motion feature, and raw frame difference. A shared ResNet-34 encoder extracts spatial features, ConvLSTM integrates temporal dependencies, and a U-Net decoder reconstructs a dense probability heatmap. The final coordinates are extracted via a soft-argmax operation to achieve sub-pixel localization accuracy. Experimental results demonstrate that this spatiotemporal fusion strategy significantly improves localization robustness compared to conventional baselines.

Abstract: Ropes, cables, and other deformable linear objects appear in tasks from untangling to cable routing and suturing, yet controlling their shape remains a challenge in robot manipulation. We study model-based shape control in a general setting: the object lies unfixated on a support surface and two arms may grasp and move it anywhere along its length. Because each arm chooses a grasp point, direction, and magnitude, the joint action space is combinatorially large, and the dynamics model's per-prediction cost bounds how much of it a planner can search. We present ForwardDLO, a recurrent latent dynamics model for this unfixated bimanual setting that predicts per-segment displacements grounded in the observed rope state at every step. Our model reaches accuracy comparable to more expensive baselines while containing no explicit segment-to-segment operations, which makes batched evaluation of candidate actions cheap. On open-loop prediction of real rope motion it reaches the lowest error of the learned models we evaluate, 13% below the strongest baseline. Within a fixed time budget it scores 8 to 22 times more candidate actions than models of comparable accuracy while matching them in real-world shape matching; and on a simulated routing task at a 30Hz control rate, this throughput converts into 98% task success versus at most 30% for the baselines at their own budgets. We release the model, code, and a dataset of 2.42 million simulated and 14,107 real rope transitions at https://anonymous.4open.science/r/ForwardDLO/

Abstract: Over the years, Convolutional Neural Networks (CNNs) have demonstrated strong capability in cancer detection and classification using medical images. However, CNN-based models often struggle to capture long-range contextual dependencies. In such scenarios, integrating Compact Convolutional Transformer (CCT) architectures after the CCT layer allows CNN-extracted features to reshape into compact patch tokens using a CCT tokenizer, followed by the addition of positional embeddings to preserve spatial structure. Using 5-fold cross-validation, the model was tested on 3 sets of breast cancer mammography. With only 250,435 parameters, the model achieved 99%-100% accuracy across 3 datasets, indicating robust generalization. Explainable AI (XAI) was integrated into the model to explain the breast cancer classification process to enhance clinical trust. The results indicate that the proposed framework is suitable for computer-aided diagnosis systems, particularly in resource-constrained clinical environments. The novelty of the proposed CNN-integrated CCT overcomes the limitation of CNN's gradient degradation in the last layers by integrating convolutional tokenization with transformer-based learning. Lighter than ViT, which is effective in capturing long-range dependencies, the model has also proven efficient in breast cancer classification by capturing long-range dependencies among breast tissue regions.

Abstract: Forecasting anatomical changes such as tumor growth and neurodegeneration is a challenging generative vision task. Morphological evolution is subtle relative to static anatomy, highly patient-specific, and inherently stochastic. Existing methods struggle with several issues: deterministic networks ignore biological stochasticity, while standard diffusion models require computationally prohibitive multi-pass sampling to quantify uncertainty. We propose MUMINS (Metadata-conditioned Uncertainty-aware Medical Image Next-state Synthesis), an efficient diffusion framework that jointly diffuses a baseline scan and its follow-up residual, summed to synthesize the follow-up scan, while concurrently predicting a spatial uncertainty map, in a single reverse diffusion process. Conditioned on the time interval and relevant metadata, it preserves fine-grained anatomy by dynamically re-injecting the baseline as a soft anchor at every denoising step, and a negative-log-likelihood head learns the uncertainty map to explicitly flag error-prone regions. Designed without organ-specific heuristics, the same architecture is reused across anatomies via separate, dataset-specific retraining. Extensive evaluations demonstrate that dataset-specific retraining of MUMINS matches or outperforms dedicated, domain-specific state-of-the-art methods on lung CT (PNG) and brain MRI (OASIS-3). Project page: https://github.com/aolivtous/MUMINS.

Abstract: Background: Large language models (LLMs) have achieved physician-comparable performance on multiple-choice medical knowledge examinations, but their capabilities in clinical history taking, urgency assessment, and safety remain insufficiently evaluated. We proposed Japanese Stroke LLM Evaluation, a multi-turn conversational benchmark for stroke care in Japanese, and evaluated LLM performance and safety under practice-oriented conditions. Methods: We created 10 stroke and related-condition cases and evaluated LLMs in multi-turn Japanese conversations. The LLM acted as physician, while a board-certified neurosurgeon acted as simulated patient and evaluator. Each case comprised history-taking and action phases scored using pre-specified criteria. Errors that could directly threaten life were defined as critical mistakes. The safety threshold was at least 80% overall with zero critical mistakes. Eighteen models were evaluated in October 2025 and June 2026. Results: Claude Fable 5 achieved the highest score (87.4%) with zero critical mistakes, followed by Claude Opus 4.7 (80.3%) and GLM-5.2 (75.6%). Two leaders met the safety threshold. Eleven models made 17 critical mistakes, including failure to confirm laboratory results or blood glucose before t-PA, surgery before airway stabilization, omission of cervical vascular evaluation, and t-PA outside its indication. History-taking question count correlated with history-taking score (r = 0.648, p = 0.007). Conclusions: Japanese Stroke LLM Evaluation provides a benchmark for LLM performance under practice-oriented conditions, including a cap on history-taking questions. Cases and evaluations were created by neurosurgical specialists rather than using an LLM-as-judge approach. Performance improved across cloud-based and on-premise models in 2026, with some exceeding the safety threshold. Further evaluation using real-world cases is required.

Abstract: Electrocardiogram (ECG) delineation identifies the boundaries of P waves, QRS complexes, and T waves, providing structural annotations that can guide AI models in learning to interpret ECGs. However, training accurate delineation models requires manual annotations that are scarce and time-consuming to obtain. Recent work addresses this limitation through semi-supervised learning (SSL), but the design of the architecture, particularly the decoder, has received less attention. To this end, we propose R-U-Net, an ECG delineation model that pairs a ResNet-18 encoder with a U-Net decoder. On SemiSegECG, R-U-Net outperforms the strongest evaluated ResNet-18 + fully convolutional network (FCN) head baseline in each of the 16 in-domain settings by 3.3-13.0 mIoU and achieves 82.6 mIoU in the cross-domain setting, an improvement of 8.1 mIoU. Controlled ablations show that decoder design contributes more to performance gains than the evaluated SSL methods, motivating further exploration of architectures for ECG delineation. All code is open-source at github.com/ELM-Research/ECG-Delineation.

Abstract: Collecting high-quality robot data for contact-rich manipulation tasks is essential for enabling robots to acquire real-world skills. However, existing data collection solutions often lack the capability to obtain stable and high-frequency tactile feedback, limiting their effectiveness in contact-rich manipulation scenarios. In this work, we propose a versatile teleoperation system with tactile-driven assistance to enable high-frequency and stable contact-rich manipulation. The proposed XRoboToolKit-T teleoperation system incorporates a tactile-informed force control architecture, designed to ensure both stable and precise force control in contact-rich manipulation during teleoperation. The stabilizer haptic module rapidly analyzes the normal force distribution and infers pseudo shear force, enabling real-time tactile-based assistance during manipulation. The refiner haptic module integrates a vision-language-action model to predict and refine manipulation actions based on tactile sensing data and task descriptions. We apply the proposed teleoperation system to challenging contact-rich manipulation tasks, including grasping a deformable rubber pipette for liquid transfer and inserting a medical syringe into a vascular training pad, to demonstrate the effectiveness of tactile-informed force control. Furthermore, the system achieves higher data collection efficiency and improved manipulation stability compared to state-of-the-art teleoperation without tactile assistance.

Abstract: Continuum robots enable smooth shape morphing and safe interaction in confined environments. However, most existing systems are task-specific and depend on external sensing infrastructure, limiting their adaptability and real-world deployment. This paper presents a self-contained modular continuum robotic platform that combines mechanical reconfigurability with onboard pose estimation. The robot is constructed from interchangeable continuum joints with analytically precomputed stiffness, allowing rapid assembly and direct programming of the robot shape. Proprioceptive sensing is achieved using magnetic sensors and a modular learning-based framework, where a single model is trained per joint and reused across configurations. The system is experimentally validated in real world, demonstrating self-sensing capabilities and adaptation without external tracking.

Abstract: Recurrent Transformers reusing their weights rather than stacking $L$ distinct layers are becoming widely adopted due to their parameter efficiency [1,2,3]. However, the exact representational and dynamical differences between looped and stacked architectures remain uncharacterized. This paper presents a controlled study on the example of bViT model [1] applying one weight-tied block $L$ times. We train two models: bViT and standard ViT [4] on 12-lead electrocardiogram (ECG) classification tasks from the PTB-XL dataset under identical training protocols. Despite an $8.9\times$ parameter reduction, bViT achieves accuracy parity with ViT. Geometric similarity metrics demonstrate that both architectures construct comparable latent representations in an equivalent canonical order. Crucially, their dynamics differ: bViT exhibits smaller step sizes and inter-patient sensitivity, as well as near-neutral behavior away from the data manifold, whereas ViT exhibits collapsing dimensionality of representations and out-of-distribution feature expansion.

Abstract: Tokenization determines both the physiological content presented to an ECG Transformer and the sequence over which attention operates. We compare eight tokenization strategies across Transformer, Informer, Reformer, and FEDformer on the nine-label CPSC2018 classification task. The input projection and principal backbone capacity are controlled to isolate the effect of token construction. Median-beat and HeartLang tokenization achieve mean macro-AUCs of 0.893 and 0.889 across the four backbones, compared with 0.822 and 0.824 for point-wise and patch-wise tokenization. Pooling the two physiology-aware representations yields an 8.2% relative improvement in macro-AUC. They also reduce mean sequence length from 1,250 to 158 tokens and mean peak training memory from 5.21 to 0.27 GB. The results show that aligning tokens with ECG morphology can improve both predictive performance and memory efficiency without increasing backbone capacity. The source code is available on https://github.com/LeeJarvis996/ecg_tokenizer.

Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which early assessment remains challenging, particularly in low-resource settings where MRI is often unavailable. High-resolution ultrasound (HRUS) of the tongue offers a portable and low-cost alternative for evaluating bulbar involvement, but learning reliable diagnostic models is limited by small datasets and the difficulty of extracting robust representations from ultrasound alone. We propose AlignUS, a cross-modal knowledge distillation framework that transfers anatomical knowledge from MRI to a HRUS-based classifier while requiring only HRUS at inference time. The model combines classification loss, supervised contrastive learning, and feature-level distillation to align HRUS representations with MRI embeddings. AlignUS achieves a patient-level balanced accuracy of 0.958, macro-F1 of 0.963, and ROC-AUC of 0.990, aggregated across four patient-level cross-validation folds, with consistent improvements over HRUS baselines and cross-modal alternatives. These results demonstrate that MRI-derived supervision can substantially improve ultrasound-based ALS assessment while preserving low-cost, inference-time independence from MRI.

Abstract: woma is a real-time foundation model for gastrointestinal endoscopy: a network trained without labels on about a million endoscopy frames, from which task models are fine-tuned. We contribute a systematic design for production. Requirements and pass marks were fixed before any run, eight candidates screened under pre-registered rules, self-supervised training taken to a stopping rule, then fine-tuning and deployment optimisation, all on one self-contained library, numbat. We also contribute woma itself with two fine-tuned models, every outcome reported met or missed. Our colonoscopy model finds and outlines polyps, names which colon segment is in view, suggests polyp type and grades bowel preparation. Our gastroscopy model names a station out of 22 protocol sites, flags and outlines lesions, and names one of seven findings. Every number was read on data never seen in training, and shipped weights were chosen on that record. In colonoscopy, 96% of polyps in a six-hospital PolypGen set are found at precision >=0.85, and 19 of 19 polyps across fifteen full REAL-Colon videos at 1.6 false alarms per procedure. In gastroscopy, landmark region is named correctly on 92% of frames from unseen patients, and 37 of 39 held-out neoplasia frames are flagged at specificity 0.91. On one workstation GPU every task runs over 1080p video at about 100 frames per second, faster than PyTorch, ONNX Runtime and TensorRT in all four precision regimes tested. TensorRT comes closest: one pass of our foundation model takes it 3 to 27% longer than ours, and we deliver 6 to 31% more frames per second from frame to results. A second build links no vendor library at all -- our own kernels over Vulkan -- so a site deploys two files and needs no toolkit, no cuDNN and no framework; in f32 it beats the CUDA build on the same card.

Abstract: Robust point tracking in endoscopic videos is essential for computer-assisted intervention and autonomous robotic surgery, enabling continuous registration between intraoperative video and preoperative imaging despite soft tissue deformation. However, supervised tracking methods depend on large annotated datasets, while surgical conditions make reliable trajectory annotation challenging. We propose a self-supervised Track-Any-Point approach that learns from unlabeled surgical videos by establishing global pixel correspondences and inferring point trajectories through contrastive random walks. Trained without annotations, our method achieves performance comparable to existing semi-supervised approaches while implicitly handling tissue deformation. These findings demonstrate the feasibility of self-supervised point tracking in surgical environments and its potential to reduce reliance on annotated data.

Abstract: Twinning the brain means reproducing its electrical activity with fidelity. This activity arises from many neuronal mechanisms across several scales, from a single neuron to whole brain regions. Current large initiatives rely on models that each capture only a few of these mechanisms. Some act at the scale of a single neuron, others at the scale of neuronal populations. No single model captures both scales with fidelity. We propose a new stochastic model, based on a combination of Random Neural Networks and Markov-Modulated Poisson Processes, that would improve the fidelity of a brain digital twin. We map the model to the Discrete Event System Specification. This yields an initial executable simulation model suitable for incorporation into a brain digital twin.

Abstract: Sparse-view computed tomography (CT) reduces radiation dose and acquisition time but remains severely ill-posed because incomplete projections poorly constrain null-space information. Existing learning-based methods often estimate this information in high-dimensional image space, conflate physical measurement errors with prediction errors, and depend on fixed discretizations. We propose SONAR, a Structure-Consistent Neural Operator for Null-Space-Aware Reconstruction. Instead of recovering the full null-space component, SONAR predicts a low-dimensional null-space-aware representation from the acquired projections as pseudo-measurements. It separates measurement and pseudo-measurement residuals, lifts them into the image domain through physics operators, and applies independent neural operators to constrain their structural effects, thereby accommodating admissible errors while suppressing unsupported structures. To support cross-discretization reconstruction, an anisotropic U-shaped neural operator models the periodic angular and nonperiodic detector dimensions using direction-dependent continuous supports, while image-domain neural operators re-discretize continuous kernels on target grids. These components form an optimization-inspired unrolled network. Experiments on simulated AAPM and clinical MARS photon-counting CT data demonstrate consistent improvements across seen and unseen view settings and unseen image resolutions. On AAPM dataset, SONAR improves PSNR by 1.87~dB at 62 views and by 7.63~dB under zero-shot transfer to a $512\times512$ grid over the strongest competing methods. SONAR also achieves the best overall performance in all clinical settings evaluated, demonstrating accurate, structurally reliable, and discretization-robust sparse-view CT reconstruction.

Abstract: This paper presents an MRI-guided robotic system that improves hippocampal access by delivering a curved needle-like laser ablator through the foramen ovale, a natural opening in the base of the skull. Both the delivery path and the curved nature of the needle improve upon current clinical straight-line laser interstitial thermal therapy (LITT) as measured by hippocampal cannulation percentage. We describe the design of the robotic system which includes positioning, aiming, and curved needle deployment stages, followed by experimental results assessing cannulation percentages using MRI images in phantoms. In three curvilinear, single-insertion experiments, we achieved cannulation percentages of 93.5%, 96.5%, and 60.4%, exceeding reported clinical averages of 50-60%. Seizure control is believed by physicians to be a function of hippocampal volume treated, and our system provides a means of treating a greater volume of the hippocampus with LITT-based interventions.

Abstract: Brain-computer interfaces (BCIs) decode neural activity to restore lost function. Typically, training a high-performance neural decoder requires a large labeled dataset to be collected from every new subject. One way to reduce the labeled data cost is self-supervised pretraining, which learns general neural representations from unlabeled recordings that accumulate across subjects. However, for intracranial electroencephalography (iEEG) recordings, self-supervised learning has been challenging due to differences in contact placement and neuroanatomy between subjects. We propose MAPA, an otherwise vanilla masked autoencoder with two spatial encodings, an anatomical region embedding and a relative positional encoding, which together enable it to learn neural representations that transfer to unseen subjects and across various tasks. MAPA sets a new state of the art across all three regimes of the Neuroprobe benchmark without fine-tuning: within-session, cross-session, and cross-subject. In the cross-subject regime, a linear probe on MAPA's features needs only ${\sim}164$ labeled trials to reach the accuracy that takes 3,500 without pretraining. Our results show that self-supervised pretraining can scale across heterogeneous iEEG recordings and reduce the labeled data needed for accurate decoding in new subjects.

Abstract: Single Ventricle Physiology (SVP) is a rare subtype of congenital heart disease characterized by the presence of a single functional cardiac ventricle with atypical anatomic configurations that challenge conventional image segmentation approaches. The scarcity of clinical data and the morphological diversity across SVP subtypes make the development of robust segmentation methods particularly difficult. To address these limitations, we propose a cardiac MRI segmentation framework focused on ventricular chambers and myocardium segmentation tailored for SVP. First, we introduce a data augmentation pipeline that generates synthetic 3D cardiac meshes using SDF4CHD and corresponding synthetic cardiac MRI through generative modeling. Second, we introduce SV-Cine, a diagnosis-conditioned adaptation of the foundation model CineMA that incorporates patient-level diagnostic information through Feature-wise Linear Modulation layers, enabling diagnosis-aware feature adaptation during segmentation. We evaluated the framework on an internal cohort with varying SVP subtypes. SV-Cine achieved median Dice scores of 0.89 (IQR: 0.80--0.91) for the left ventricle and 0.72 (IQR: 0.54--0.84) for the right ventricle, outperforming the strongest baseline, nnU-Net, by 0.39 Dice points on right ventricle segmentation. It also yields a median ejection fraction error of 5.55 percentage points (IQR: 3.41--7.69) for the dominant ventricle. Compared with the internal cohort, LV and myocardium segmentation performance was lower for the external cohort; whereas RV Dice scores were comparable for both cohorts. Our findings suggest that a pretrained foundation model can be adapted for highly specialized downstream tasks through usage of diagnosis priors while leveraging anatomic knowledge learned from large-scale MRI datasets during pretraining.

Abstract: Accurate biomedical image segmentation requires not only high global overlap but also reliable delineation of clinically meaningful boundaries. In blood-smear microscopy, cytoplasm and nucleus contours provide the structural basis for downstream morphology analysis; however, deep segmentation models may remain uncertain or overconfident near ambiguous boundary regions even when achieving strong Dice scores. This work proposes a Reliability-Aware Boundary Refinement Network (RABR-Net), a two-stage framework for trustworthy image segmentation. A strong UNet++ EfficientNet-B4 base segmenter first produces initial class probabilities and logits. Predictive entropy, test-time augmentation variance, margin uncertainty, probability gradients, and soft boundary cues are then combined into a boundary-aware reliability representation. This representation guides a gated residual refiner that selectively corrects uncertain boundary pixels while preserving confident regions of the base prediction. The framework is evaluated using overlap accuracy, class-wise Dice, Boundary Dice, HD95/ASSD, calibration, risk--coverage analysis, robustness under image perturbations, qualitative correction maps, and paired statistical testing. On the held-out test set, the proposed method improves Dice from 0.9602 to 0.9614, Boundary Dice from 0.3448 to 0.3611, and HD95 from 3.0354 to 2.8274 compared with the cached base prediction. Statistical analysis confirms significant improvements in Dice, Boundary Dice, and HD95. Qualitative results show that the learned gate concentrates around uncertain cytoplasm and nucleus boundaries, and correction maps confirm localized boundary refinement. Although calibration does not automatically improve after refinement, the proposed framework provides an interpretable and reliability-focused strategy for boundary-sensitive biomedical image segmentation.

Abstract: In the VTaC benchmark 71% of ventricular-tachycardia alarms are false, but silencing a real one can delay recognition of a dangerous arrhythmia. We reframe alarm reduction as three-way triage (retain, suppress, or defer) and bound the decision this analysis treats as harmful: among suppressed alarms, the fraction that were genuine stays below a user-set budget with 95% confidence, under i.i.d. event sampling. Alarms sharing a waveform record are dependent, so the clustered analysis is a sensitivity check. On the official split a 5% budget certifies in all three seeds, suppressing 74.8% of false alarms while silencing 1.5% of genuine ones, at AUROC 0.953 and Challenge Score 83.33, numerically comparable to the strongest of the eleven published systems. Our central finding measures what multiplicity costs: the correction charges for every candidate, so a finer grid can certify strictly less. Under held-out calibration the 885-cell grid we declared certifies 1 of 15 fold-runs, while choosing the grid on a separate selection partition certifies 8. We project the calibration volume each budget needs, making an uncertifiable budget a design parameter. Finally, adding a learned reliability dimension to the policy grid did not sharpen the certified frontier.

Abstract: The growing use of electroencephalography (EEG) motivates automated analysis that is accurate, transferable, and deployable on constrained hardware. Recent EEG foundation models learn general representations from large-scale pretraining, but their size and computational cost limit edge and wearable deployment. We introduce BRIDGE-EEG, an efficient multi-task EEG classification pipeline that preserves the benefits of pretraining while reducing model size. A unified preprocessing scheme maps heterogeneous recordings with different channel counts, montages, and sampling rates to a device-agnostic 62-channel time--frequency representation. We pretrain an SE-ResNet18 teacher (11.84 M parameters) with SimCLR on unlabeled EEG from five heterogeneous datasets, then compress it into SE-ResNet8 (1.56 M) and SE-ResNet4 (0.48 M) students using task-agnostic and task-specific distillation. We evaluate six benchmarks spanning abnormality detection, motor imagery, and emotion recognition. For abnormality detection and emotion recognition, the students achieve accuracy comparable to or better than several recent EEG foundation models with 10--1,000$\times$ more parameters. Motor imagery shows a remaining representation gap, highlighting the importance of pretraining diversity. Inference profiling on a server GPU, desktop CPU, and NVIDIA Jetson Orin Nano shows up to 3.0$\times$ lower edge energy per inference (15.64 mJ vs. 46.67 mJ). The compact models further support future deployment on MCU-class wearables.

Abstract: Brain age estimation has become a popular research proxy for assessing brain health and disease, yet longitudinal trajectories of brain ageing are still poorly defined, and clinical use is limited. Building on existing Siamese longitudinal frameworks, we develop Brain-Predicted Age Acceleration (Brain-PACE) to directly estimate the pace of structural brain ageing from paired T1-weighted MRI. Brain-PACE identified accelerated ageing in $42.6$% of participants with mild cognitive impairment. Faster Brain-PACE was associated with greater functional and cognitive impairment (FAQ; $r=0.35$, ADAS13; $r=0.30$, CDR-SB; $r=0.32$) and greater regional tau burden in the posterior cingulate ($r=0.59$), precuneus ($r=0.47$), and entorhinal cortex ($r=0.37$). These associations were stronger than those observed when pace was calculated indirectly from repeated cross-sectional brain age estimates, suggesting that direct longitudinal modelling captures complementary information relevant to ongoing pathological change. Methodologically, Brain-PACE extends the LILAC framework by combining spatial attention with soft label distribution learning and a Cramér distance objective, improving probabilistic performance and reducing prediction bias while providing measures of predictive uncertainty. Together, these findings support Brain-PACE as a complementary longitudinal imaging phenotype with sensitivity to relevant clinical and biological changes in early neurodegeneration.

Abstract: Optical coherence tomography is a promising modality for markerless motion tracking due to its high spatial resolution and inherent depth perception. However, existing OCT-based tracking approaches are limited in terms of trackable velocity, particularly when multiple landmarks are tracked sequentially for 6D pose estimation. In this work, we present a predictive tracking approach that propagates positional updates between multiple tracked landmarks to obtain a global pose prediction. This enables more robust tracking under high velocities. Our results demonstrate RMSEs below 1 mm for velocities up to 100 mm/s and up to nine consecutively tracked landmarks, highlighting the potential of global motion propagation and prediction for improving the robustness of OCT-based tracking.

Abstract: Preoperative prediction of perineural invasion (PNI) in cholangiocarcinoma (CCA) is clinically valuable but remains challenging because PNI-related cues on magnetic resonance imaging (MRI) are subtle, sparse, and spatially localized around the tumor boundary. Standard 3D CNN and transformer architectures process volumetric data in a dense or spatially uniform manner, which can dilute subtle PNI-related evidence while requiring a large number of multiply-accumulate operations over 3D feature grids. To address these limitations, we propose SCINTILLA-SNN, a 3D spiking network composed of a four-stage hierarchical backbone and a Multi-Scale Spike Aggregation (MSSA) module for PNI prediction. The backbone extracts hierarchical volumetric representations through spiking convolutional stages and local spike window modulation stages. Given the resulting stage-wise representations, MSSA maps each spatial token to a learnable content value and modulates it with a spike-dynamics gate derived from firing rate and timestep-wise membrane-potential variability. The resulting score, referred to as the diagnostic token score, is used to selectively aggregate sparse PNI-related evidence. Experiments on a 10-year retrospective cohort of 182 CCA patients show that SCINTILLA-SNN achieves an AUROC of 0.748 under 5-fold cross-validation, while reducing the estimated inference energy by 23.18$\times$ compared with dense MAC-only computation of the same network.

Abstract: Diffeomorphic image registration is central to medical image analysis, enabling anatomically consistent alignment across subjects. Most learning-based diffeomorphic methods model autonomous ODEs(ordinary differential equations) by parameterizing a stationary velocity field and recovering deformations via scaling-and-squaring. While non-autonomous ODEs with time-dependent velocities increase expressiveness, existing approaches rely on numerical integration to implicitly enforce flow structure that entangles model expressiveness with discretization accuracy. We propose a framework to directly learn the continuous-time solution of a non-autonomous ODE formulated as a two-parameterflow map. By enforcing cocycle consistency, a fundamental structural property of time-varying flows, we learn the flow maps without time discretization and velocity integration during training. The framework recovers diffeomorphic mappings at inference using a small number of compositions. Our proposed framework seamlessly incorporates standard registration backbones and improves alignment accuracy consistently across nine datasets while preserving diffeomorphic structure. Notably, the proposed method achieves an average Dice improvement of 2.1% on brain MRI benchmarks, a 12% TRE reduction on lung CT, and a 2.6% Dice gain on cardiac MRI and ultrasound datasets.

Abstract: Sparse-view X-ray 3D reconstruction is essential for reducing radiation exposure, but recovering a density field from a handful of X-ray projections is severely ill-posed. Recently, 3D Gaussian Splatting has achieved state-of-the-art performance in sparse-view reconstruction by representing the volume using explicit, optimized primitives, but it requires dozens of projected views. With fewer views, reconstruction quality degrades severely since the explicit primitives are optimized freely without any anatomical information. Anatomical structures, in contrast, share similar geometry and density across a population. Their variations are bounded within a limited range that statistical shape models can capture. This paper proposes a shape-guided Gaussian splatting framework for sparse-view X-ray 3D reconstructions. Our contribution lies in driving Gaussian positions toward anatomically valid configurations, alongside atlas-based density regularization. Our method ensures anatomically consistent reconstruction and improves PSNR by 2.83 dB over a state-of-the-art Gaussian splatting baseline with as few as 5 views. Code Available: https://github.com/polyshape-lab/ShapeGuidedGaussian

Abstract: Speech-based Alzheimer's disease (AD) detection has recently benefited from multimodal foundation-model representations that integrate complementary acoustic and linguistic information. However, conventional probability averaging over these complementary classifiers is unreliable, because their posterior probabilities exhibit mismatched scales: identical values may reflect different confidence levels across models. We propose a robust rank aggregation framework that aggregates normalized prediction ranks instead of posterior probabilities. Each subject is scored by its percentile within a fixed training-cohort distribution of out-of-fold predictions; since rank ordering is invariant to monotonic transformations, this avoids probability-scale mismatch while preserving classifier confidence ordering. A confidence-gated Random Forest further corrects residual errors using clinically interpretable linguistic features, overriding the rank prediction only when the two disagree and the RF is highly confident, without additional deep model training or explicit posterior-probability calibration. On ADReSS2020 and ADReSSo2021, the method achieves accuracies of 95.83% and 90.14%, respectively, comparing favorably with previously reported results.

Abstract: Parkinson's disease is a progressive neurodegenerative disorder characterised by gradual deterioration of movement control. Automated freezing-of-gait (FOG) detection supports the objective assessment of gait-related motor impairment. Two common approaches are used for FOG prediction: (i) analysing video recordings of the patient's movements and (ii) analysing data collected using inertial measurement unit (IMU) wearable sensors attached to the patient's lower limbs. Video-based approaches may suffer detection errors during continuous turning-in-place tasks because the lower limbs undergo substantial geometric self-occlusion, degrading pose-estimation accuracy. IMU-based approaches are generally less affected by visual occlusion; however, they are difficult to deploy outside clinical or laboratory settings, as the sensors must be attached securely and remain in place throughout the assessment. Motivated by this, we propose a cross-modal subspace distillation framework to mitigate the limitations of unimodal FOG detection by combining IMU accuracy with video-based practicality. We extract invariant latent topologies from a pre-trained kinematic oracle to structurally supervise a non-encoded visual architecture during training. To resolve periods of severe spatial occlusion, a dual-stream visual model probabilistically fuses skeletal graph nodes and continuous spatial pixels, dynamically shifting reliance to uninterrupted pixel boundaries as joint tracking confidence drops. Evaluated against a public, multi-modal sequence dataset of Parkinson's individuals executing continuous $360^\circ$ turns, empirical results demonstrate that applying sensory boundary topologies strictly mitigates tracking evaluation entropy. Our constrained optimisation confirms that highly precise FOG prediction bounds can be achieved over zero-wearable inference environments.

Abstract: Electroencephalography (EEG)-based motor-imagery brain-computer interfaces (MI-BCIs) vary across subjects and sessions, complicating personalization from limited calibration data. Federated learning can exploit shared representations without centralizing raw EEG, but existing federated MI studies largely assume regular synchronization. We introduce NEXUS-MI, a gateway-coordinated federated personalization framework that treats synchronization as a coupled learning-and-communication control problem. Raw EEG and classifier heads remain local, while an edge coordinator maintains the shared backbone. We evaluate NEXUS-MI through offline replay using BCI Competition IV Dataset 2a (BCICIV-2a; 9 subjects, 4 classes) and OpenBMI (54 subjects, 2 classes). Session 1 supports backbone learning, and Session 2 provides limited-calibration personalization and held-out testing. An ideal-link reference and six heterogeneous-link policies characterize gateway participation, buffering, stale-update admission, and backbone-download control. The principal comparison holds delayed-update handling fixed while contrasting non-adaptive and communication-aware synchronization. Paired subject-level comparisons use Holm adjustment, and robustness across five matched realizations is assessed by hierarchical bootstrap. Communication-aware coordination reduced server-to-client backbone traffic by approximately 42% on both datasets, while cohort-level accuracy differences were small and realization-dependent. Cohort averages also concealed subject-level vulnerability, with losses reaching approximately 12 percentage points on BCICIV-2a relative to the ideal-link reference. These findings establish gateway synchronization as an explicit design variable in federated MI personalization and motivate joint evaluation of personalized accuracy, communication cost, update freshness, and subject-level reliability.

Abstract: We present the PccDiffuser, a conditional diffusion framework for continuum robots that learns a multimodal distribution over complete configuration-space paths and samples multiple candidate solutions in parallel, which are subsequently converted into an executable trajectory by time allocation considering actuator constraints. Under the piecewise constant-curvature model, we use exponential co-ordinates to describe the robot kinematics, and use graph neural network to encode a variable number of environment obstacles. Analytical differential kinematics is incorporated in the denoising process to improve terminal accuracy and whole-body clearance. On a mixed test set comprising workspace with zero to four obstacles, PccDiffuser achieved a success rate of 91\%. Compared with existing sampling- and optimisation-based benchmarks, it delivered both a higher success rate and greater computational efficiency, with the latter advantage becoming more substantial when sampling more candidate solutions. Experiments on a three-section tendon-driven continuum robot further demonstrate consecutive planning, multi-solution planning, and whole-body obstacle avoidance.

Abstract: False ventricular tachycardia (VT) alarms are a leading contributor to alarm fatigue in intensive care units. We propose a deep learning framework combining a 1D SE-ResNet with ICU-realistic data augmentations and a physics-informed auxiliary reconstruction task based on the three-element Windkessel hemodynamic model, implemented as a differentiable forward simulation. By requiring the network's latent representation to produce physiologically plausible arterial pressure waveforms, artifact-driven ECG patterns are penalized while true VT remains coherent across modalities. Evaluated on the VTaC benchmark under a strict real-time protocol (10-second pre-alarm window), our method achieves a 5-point Challenge Score improvement over prior state-of-the-art. Ablation studies confirm that the physics-informed objective is the primary performance driver, providing gains in accuracy, 2x label efficiency, and more localized and clinically meaningful ECG segments.

Abstract: Dense self-attention treats all token pairs as equally plausible before learning, an interaction-isotropic prior that can be mismatched to structured signals. For structured, low signal-to-noise ratio (SNR) signals such as EEG, dependencies are organized along the electrode and time axes, and this uniform prior exposes each token to many irrelevant interactions. We introduce Adaptive Anisotropic Attention (AAA), which splits attention into two paths: a temporal path, where each token attends to the tokens of its own electrode across time, and a spatial path, where it attends to the tokens of the other electrodes at the same time step. A small gate predicts, for every token, a convex combination of the two path outputs: two non-negative weights that sum to one. On six EEG downstream tasks, the resulting model, AXON (AXis-factorized Operator Network), improves mean balanced accuracy over a dense baseline under both linear probing and full fine-tuning. We show that both paths (temporal and spatial) are necessary and that the weighted sum beats a hard choice of one path; most of the benefit comes from the gate learning a different temporal/spatial balance at each layer of the network. Controlled audio spectrogram experiments show that axis factorization transfers beyond EEG. These results suggest that aligning attention with the natural axes of structured signals provides a useful inductive bias.

Abstract: Chagas disease is a major cause of cardiomyopathy in Latin America. Cardiac magnetic resonance (CMR) imaging can characterize its structural abnormalities, but scanners and expert readers remain scarce in endemic regions. Electrocardiography (ECG) is inexpensive and widely available, yet structural disease must be inferred indirectly from electrical signals. We propose to transfer CMR-derived structural knowledge to ECG through contrastive pre-training. Using 63,193 paired ECG-CMR examinations from the UK Biobank, we align an ECG encoder with a clinically grounded CMR embedding space using an asymmetric InfoNCE objective. Despite seeing no Chagas cases during pre-training, the resulting representation improves ECG-based Chagas detection. Across CODE-15% and SaMi-Trop, a frozen linear probe achieves an AUROC of 0.851 and sensitivity at the top 5% of predicted risk (Top5%-TPR) of 0.427 in five-fold cross-validation, compared with 0.827 and 0.377 for an unaligned ECG-FM baseline. On the PhysioNet/CinC 2025 Challenge test set, our model obtains the highest AUROC on SaMi-Trop-3 and the best ELSA-Brasil challenge score among the three top-performing methods, indicating that imaging-supervised ECG representations can generalize to populations and settings beyond the pre-training distribution.

Abstract: Reconstructing a three-dimensional left-ventricular (LV) endocardial surface from cardiac magnetic resonance (CMR) data is challenging when supervision is available on only a small number of axial slices. Through-plane geometry is weakly constrained, and automatically generated two-dimensional masks can propagate segmentation errors into the recovered shape. We present MR-RS-SDFR, a per-case implicit signed distance field (SDF) framework that reconstructs a continuous LV surface from a CMR volume and sparse axial weak masks. The method first builds a cross-slice SDF initialization from axial and longitudinal geometric cues and then refines the field using two complementary signals: MRI edge-field normal alignment, which provides an image-derived boundary cue independent of the weak masks, and differentiable reslice Dice and contour consistency, which preserve agreement with the observed planes. We evaluate three weak-mask generators -- LOO TransUNet, LOO nnU-Net, and an off-the-shelf Medical SAM3 model used without MM-WHS-specific training or fine-tuning -- and five sparsity levels from 4 to 64 axial planes. In the sparse-16 setting, final MR-RS-SDFR reconstruction reaches 0.928 Dice and 3.80mm HD95 with Medical SAM3 masks. The upstream generators do not exhibit a single common ranking across 2D and dense 3D segmentation, and nnU-Net- and Medical-SAM3-driven sparse reconstruction achieve the same mean final Dice despite different upstream error profiles. Across all three sparse-16 mask sources, MR-RS-SDFR is numerically better than protocol-matched full GHD+DVS in both Dice and HD95. Final Dice improves markedly from sparse-4 to sparse-16 and then saturates at the reported precision through sparse-64. These results support MRI-guided per-case SDF refinement as a reconstruction strategy that remains effective across weak-mask generators and supervision densities.

Abstract: Robotic ophthalmic surgery offers high precision but introduces a "sensory gap" by decoupling the surgeon from their instrument, resulting in a loss of tactile feedback. This paper presents a novel haptic feedback system for subretinal injection tasks leveraging Scene Graphs (SG). The system bridges the sensory gap by analyzing a physically simulated intraoperative Optical Coherence Tomography (iOCT) feed to construct a real-time surgical SG. The SG serves as a semantic abstraction layer for the surgical scene, which is then utilized by a deterministic, rule-based engine to generate state-dependent haptic feedback on a robotic input device. The system was evaluated in a user study (N=16) using an anthropomorphic head phantom and a custom-built surgical robot. Results demonstrate that the SG-driven haptic feedback improved surgical precision, reducing needle alignment error by 14% (p = 0.044) and improving System Usability Scale (SUS) scores by 8% (p = 0.015), while maintaining comparable task completion times. A needle trajectory analysis revealed the emergence of a safer "Align-then-Approach" strategy, in which our haptic negative reinforcement prompted users to fine-tune the tool's trajectory before approaching the retinal target. This work suggests that SGs can effectively serve as the direct computational foundation for real-time, safety-enhancing context-aware haptic feedback in robotic microsurgery.

Abstract: In-body subnetworks (IBSs) are expected to become a key enabler of immersive eXtended Reality (XR) services in sixth-generation (6G) networks by providing ultra-short-range, low-latency wireless connectivity around the human body. However, the dense coexistence of multiple IBSs leads to severe co-channel interference, requiring increased transmit power to satisfy the stringent latency requirements of XR applications. Existing interference management approaches allocate radio resources solely according to application-level Quality-of-Service (QoS) requirements, overlooking the perceptual limitations of human users. This paper proposes perception-aware joint power control and sub-band allocation framework that integrates users' delay perception into radio resource allocation for XR-oriented IBSs. A learning-based perception model is first developed by combining Gaussian mixture modeling (GMM) with supervised learning to develop a statistical model of the delay perception threshold. The learned perception model is then incorporated into a stochastic radio resource allocation problem, which is reformulated using a Lyapunov drift-plus-penalty and solved through a low-complexity per-slot resource allocation procedure. System-level simulations under realistic intra- and inter-IBS propagation conditions demonstrate that the proposed approach substantially improves radio resource efficiency, achieving up to 26% transmit power reduction under stringent latency requirements and approximately 60% power savings in dense IBS deployments, while maintaining the required Quality of Experience (QoE).

Abstract: In this paper, we propose a class-wise dimension (channel) selection framework for Multivariate Time Series Classification (MTSC). Rather than applying a single global dimension selection process, the proposed approach independently identifies informative dimensions for each class. A dedicated learning process is subsequently performed for each class, followed by a fusion stage for final prediction. The objective is to improve the generation of discriminative feature representations while reducing the influence of noisy or non-informative dimensions. The proposed framework is evaluated using MiniRocket, a random kernel-based baseline method. Experimental results indicate that class-wise dimension selection improves the quality of extracted representations and can enhance classification performance, particularly in high-dimensional settings. These findings suggest that incorporating class-specific information into the training process represents a promising direction for MTSC, improving robustness through consistent gains across heterogeneous datasets, and interpretability through the explicit identification of class-relevant dimensions.

Abstract: Deformability cytometry (DC) is a type of imaging flow cytometry, which uses a camera-equipped device to measure cellular stiffness in addition to other cellular properties at high throughput. Cellular properties such as area and elongation can identify cell types, but this requires prior knowledge of distinguishing properties and cannot be applied to clinically important cell aggregates. Using DC data, we evaluated conventional multi-class (MC) classification and introduced a multi-label (ML) approach for identifying blood cells and their aggregates. In particular, an ML classifier can simultaneously assign multiple cell-type labels to a single imaged event. We show that, unlike MC classification, ML classification can identify cell aggregates not represented in the training data. It also avoids the need for exhaustive, strictly defined aggregate labels, thereby simplifying and speeding up annotation. Since automated blood analyzers do not reliably analyze cell aggregates, our approach may help address this clinical gap.

Abstract: Computed Tomography (CT) is an essential 3D imaging technology widely used in medical diagnostics and scientific research. However, performing CT imaging on edge devices is challenging due to limitations in computational power, memory capacity, and energy budget. This paper presents an efficient CT reconstruction framework, called edgeFBP, designed for Nvidia Jetson System-on-Chip (SoC) devices. edgeFBP adopts an end-to-end pipeline design for efficient out-of-core image reconstruction under tight power and memory constraints. edgeFBP utilizes a mixed-precision strategy leveraging half-precision Tensor Cores (TCs) to accelerate the bottleneck back-projection (BP) kernel. edgeFBP achieves a 1.83x speedup over the widely used RTK library on Jetson Nano and a 2.56x speedup on Jetson AGX. Under a strict 25-Watt power budget, edgeFBP on Jetson Nano achieves up to 5-48x higher energy efficiency than an Nvidia DGX A100, enabling datacenter-scale imaging on constrained edge devices.

Abstract: Sparse outcome feedback limits what robots can learn from unsuccessful attempts at complex manipulation. Failed multi-stage surgical attempts can contain grasps, lifts, or transfers worth reusing. In sparse-reward reinforcement learning, terminal rewards collapse such attempts to the same outcome, while scalar vision-language model (VLM) ratings reveal neither what progress merits credit nor when it occurred. We introduce phase-and-first-arrival feedback: one VLM query per recorded episode identifies the furthest visually verified task phase and when that phase is first reached, allowing the learner to reuse partial behavior and localize credit. We instantiate it in SurgPhaseBench, a phase-structured suite spanning rigid and deformable tasks, and evaluate it in simulation and hardware. Across five simulated tasks, our method reaches 75.2% mean success, compared with 52.1% for a reward based on Contrastive Language-Image Pre-training (CLIP) using the same visual input; the advantage persists when only the feedback representation changes. On hardware, the same record supports autonomous block picking and slip recovery. Together, these results show that trajectory-level visual supervision can preserve partial progress while providing the temporal credit needed for sparse-reward control.

Abstract: Purpose: This study aims to develop an AI framework applicable for postoperative imaging for automated measurement of spinopelvic parameters on radiographs with robustness to the presence of spinal implants. Materials and Methods: We retrospectively reviewed lateral lumbar spine radiographs from two institutions (Internal: January 2017--December 2024; External: October 2021--September 2025). We developed the Restore, Segment, and Measure (RSM) framework, incorporating a novel Artifact Removal Network based on Autoencoding and Inpainting (ARNAI) to mitigate implant-related artifacts in postoperative radiographs. Segmentation and spinopelvic parameter (PT, LL, SS, SCA) measurement performance were assessed using Wilcoxon signed-rank tests and intraclass correlation coefficients. Results: When ARNAI was added to a recent Transformer-based segmentation model, FCBFormer, the mean DSC increased to 0.870 from 0.814, with marked gains at L3--L5 and smaller improvements at L1--L2. On 91 radiographs with implants, the mean L4--L5 segmental Cobb angle error decreased to 4.7 ° from 15.6--16.2 °, an average error reduction of 70%. The ICC for L4--L5 segmental Cobb angle improved to 0.54 (Rater 1) and 0.59 (Rater 2) from 0.18, and ICCs for pelvic tilt, lumbar lordosis, and sacral slope all exceeded 0.70. The improvement in L4--L5 segmental Cobb angle error was statistically significant in the internal implant-containing cohort after correction for multiple comparisons. Conclusion: The proposed RSM framework improved automated spinopelvic parameter measurement in implant-containing postoperative radiographs. By mitigating implant-related artifacts, ARNAI improved segmentation and downstream measurement accuracy, with the greatest benefit observed for L4--L5 segmental Cobb angle estimation, where the mean error was reduced by approximately 70%.

Abstract: Invasive neural recordings provide high-fidelity measurements of brain activity, with signals such as intracranial EEG (iEEG) and intracortical spiking activity capturing neural dynamics at different spatial and temporal scales. Yet existing neural foundation models have largely been developed independently for different invasive recording paradigms, leaving joint pretraining across heterogeneous invasive signals underexplored. In this work, we introduce iBrain, a unified foundation model that jointly learns from iEEG and spiking activity. iBrain employs signal-specific encoders to accommodate their distinct signal characteristics and a shared spatiotemporal Transformer backbone to model dependencies across recording channels and time. We pretrain iBrain on over 7,000 hours of heterogeneous neural recordings using masked signal reconstruction and channel-view alignment, promoting contextual modeling of neural dynamics and robustness across different channels. iBrain consistently outperforms single-signal pretraining baselines and achieves state-of-the-art performance on multiple benchmarks. Further experiments demonstrate that iBrain exhibits transferability and data efficiency across diverse recording settings. These results highlight the potential of joint pretraining on heterogeneous invasive neural recordings to support scalable neural modeling and transferable representations across recording settings and downstream tasks.