Abstract: Native-latent guidance is a recent paradigm for solving inverse problems with latent diffusion models. It replaces repeated evaluations of the image-space forward model, each requiring a decoder pass, with efficient guidance computed using a learned latent-space surrogate. However, existing methods apply guidance uniformly across latent dimensions, ignoring that measurements are informative only along certain directions and that the reliability of model predictions varies across inputs and timesteps. We propose ANaLOG, a framework for efficient uncertainty-aware guidance with pretrained latent diffusion models. ANaLOG models uncertainty by learning an anisotropic, input- and time-dependent covariance that is integrated into the guidance mechanism to emphasize reliable directions and downweight uncertain ones. We theoretically analyze this framework in a linear model setting and prove that anisotropic, uncertainty-aware weighting is necessary for correct sampling, whereas isotropic guidance induces sampling errors. Experiments across five challenging inverse problems show that ANaLOG improves perceptual reconstruction quality over existing methods while preserving efficiency.