Abstract: In cases where source code is not available, such as malware analysis, firmware analysis, and embedded systems analysis, vulnerability detection in compiled programs has gained importance. Current methods are heavily reliant on syntactical regularities or higher level representations that are vulnerable to changes in the compiler and may not be readily applicable to assembly code.In this article, we present SEMA-GUARD, a framework that uses semantic analysis and graph neural networks to identify flaws in assembly code. The approach improves the representation of control flow graphs by adding information about the program's execution at a lower level of abstraction, including stack manipulations, memory accesses, and data flow. A set based on the Juliet Test Suite was used to evaluate the effectiveness of SEMA-GUARD. In this set, each piece of source code is initially translated into assembly language and then broken down into function-level chunks. The suggested method, which relies only on statistical or structural data, achieves an accuracy of 85.1\% and an F1 score of 0.801, according to the results. Such results imply that including semantic information in graph-based models may be a successful method for identifying vulnerabilities in compiled code.