digital health platform teams

Abstract: Large language models (LLMs) have shown promise in medical question answering and clinical reasoning, yet their improvement remains constrained by static parametric knowledge and costly expert supervision. Self-evolving agents offer a promising alternative by enabling models to improve through iterative task generation and problem-solving. However, most existing self-evolving methods are designed for easily verifiable domains such as mathematics and coding, where solutions can be checked by exact answers or executable programs. Medical reasoning is fundamentally different: it is open-ended, knowledge-intensive, and often only partially verifiable. We present MedZERO, a self-evolving framework for open-ended medical reasoning. MedZERO couples an Examiner that generates frontier medical question-option pairs with a Reasoner that solves them through evidence-grounded multi-turn reasoning with external knowledge tools. To support reliable, continual improvement, MedZERO adopts controlled knowledge accumulation, which maintains temporary exploratory knowledge and curated persistent knowledge in reasoning. We evaluate MedZERO on five public medical reasoning benchmarks using 4B- and 8B-scale base models under open-ended evaluation. Across all settings, MedZERO consistently outperforms the underlying base models and prior self-evolving baselines, achieving up to 13.7 average accuracy-point gains over the next-best self-evolving baseline.

Abstract: Background: Just-in-time adaptive interventions (JITAIs) can use behavioral data to adapt support to changing contexts, but many rely on predefined rules and manual configuration. Objective: We developed a proof-of-concept sleep JITAI using an AI agent to review personal data, evaluate reminders, adapt interventions, and record decisions for human review. Methods: Running in Home Assistant on a configurable schedule, the agent follows a reusable skill file to review 30 days of sleep and behavioral data, including physical activity, smartphone use, and bedtime routines, to identify patterns and create or update automated reminders. Results: Initial runs demonstrated technical feasibility, successfully completing data review and intervention decisions while limiting reminders to three per day and saving decision records. Conclusions: Agentic AI may enable flexible, adaptive sleep JITAIs. The architecture supports future comparison with fixed or rulebased interventions, requires human oversight, and could extend to other health behaviors.

Abstract: Adolescent depression, anxiety, and stress (D/A/S) call for scalable tools that complement, rather than replace, professional evaluation. Under a privacy-preserving policy, the AdoDAS Grand Challenge withholds minors' raw recordings and distributes anonymized audio-visual representations and ASR-derived text. Its 6,000 participants provide 24,000 segments across one scripted-reading and three open-response sessions. Two tracks assess multi-task binary D/A/S screening and ordinal prediction of 21 DASS-21 item responses. From 191 registrations, the final leaderboards included 95 eligible screening teams and 64 item-prediction teams. Audio-visual baselines achieved 0.4604 mean F1 and 0.2675 mean Quadratic Weighted Kappa; leading submissions reached 0.5921 and 0.2776. Representative systems emphasize cross-session modelling, temporal multimodal fusion, psychometric structure, and task-aware calibration.