digital health platform developers

Abstract: GLP-1 medications are increasingly used for weight management, and many people share their experiences online. These narratives show why people take the drugs and what they experience, but they remain unstructured and disconnected from formal pharmacovigilance. We therefore present AskGLP1, a system that transforms online patient narratives into a knowledge graph (KG) and answers questions about medication experiences. Through an LLM-assisted pipeline grounded in the MedDRA terminology, AskGLP1 screens nearly 8.5 million Reddit posts for medication experiences and distills 163,135 of them, with 2,506 WebMD reviews, into a KG of 385,790 drug-side-effect and drug-purpose relations. We find that GLP-1 experiences are source- and drug-specific. Online narratives share the most common gastrointestinal symptoms with FAERS, but they foreground everyday burdens such as fatigue and food aversion, whereas FAERS reports more often include injection-site reactions and selected serious diagnoses such as pancreatitis. We further find that posts report less nausea and vomiting for tirzepatide than for semaglutide, more fatigue for Wegovy than Ozempic and for Zepbound than Mounjaro. Evaluations show that the agent answers with verifiable evidence and declines requests for medical advice. Our findings reveal gaps between what FAERS captures and what people report online, and they call for patient-centered approaches to pharmacovigilance. Code, prompts, and evaluation questions are available at https://github.com/ZhaoqianXue/AskGLP1.

Abstract: Autism spectrum disorder (ASD) is diagnosed through specialist observation of a child's social behavior, and access to that expertise is the bottleneck for early identification. Vision-language models (VLMs) describe a child's behavior from video well; the verdict drawn from the description is unstable: at temperature~0, across eight pipeline configurations on one backbone, 16--37\% of clips change their predicted label between repeated runs, and the cause lies in the serving stack. We keep the VLM frozen and move the decision out of the model. Under our grounded perception constraints the VLM writes an event table of timestamped, glossary-labeled events that names the eliciting press and logs counter-evidence; a text-only stage age-calibrates the confidence of each row; a deterministic weight-of-evidence scorer sums it into an evidence total and stratifies it into a risk category, so every decision decomposes into named per-feature contributions and can be re-scored from the saved table. On 43 caregiver-recorded, protocol-free home free-play clips of preschool children, the pipeline reaches AUC $0.851 \pm 0.012$, 86.0\% accuracy, and F$_1$ 71.8 over three runs. It labels 74.4\% of clips correctly in every run (60.5\% for the zero-shot baseline) and flags no typically developing clip in every run (9 of 31 at zero-shot). An ablation on the same backbone attributes the gain to the grounded perception constraints read through the deterministic scorer.