clinical decision support teams

Abstract: We describe our submission to the MedReason 2026 challenge, covering multiple-choice (MCQ) and open-ended (OE) medical visual question answering (VQA) under fully offline, containerized inference. Our first finding is that MCQ retrieval must compare answer \emph{semantics} rather than answer labels: labels are independently assigned per question, so copying a retrieved neighbor's label transfers no useful information, whereas scoring each current option's text against correct-answer text from similar training cases raises retrieval-only accuracy from 20.0\% to 57.5\% on a 200-case retrieval-excluded development holdout. Our second finding attributes the submitted system's accuracy: holding the task-specific MCQ Low-Rank Adaptation (LoRA) adapter fixed and varying the number \(k\) of in-prompt retrieved examples changes accuracy by at most one case --- 187/200 (93.5\%) at both \(k=0\) and the adapter's training-time \(k=1\), 188/200 (94.0\%) at the packaged runtime's default \(k=3\) --- and the submitted confidence-gated override adds no net accuracy on top of \(k=3\), selecting the VLM in 198/200 cases. With the final MCQ adapter fixed, retrieval changes accuracy by at most one case, and gating provides no net gain. On 20 OE cases, token-F1 and RaTEScore~\cite{zhao2024ratescore} decrease as \(k\) grows, but paired sign tests on token-F1 differences are nonsignificant (\(p \ge 0.29\)); a single-annotator comparison found 6/20 wrong-anchor errors for the final configuration and 14/20 for an earlier configuration that jointly differed in routing, adapter, and prompting. The system reaches 94.0\% MCQ accuracy on the development holdout and 93.20\% on the organizer's official pre-evaluation, versus 29.43\% for the off-the-shelf reference baseline, while both of the organizer's open-ended scores are lower than that baseline's (ground-truth agreement 1.245 versus 1.588, visual accuracy 1.995 versus 2.696, each out of 4).

Abstract: Large language model (LLM) driven multi-agent systems have shown promise in complex clinical reasoning, yet existing approaches rely on static strategies and lack persistent clinical memory, preventing self-evolving from prior diagnostic successes and failures. We present EMR, a self-evolving medical multi-agent system via Experience Mining and Reuse. EMR introduces a hierarchical clinical experience library that organizes accumulated knowledge into three levels: clinical principles, diagnostic patterns, and representative cases. During inference, EMR emulates multidisciplinary consultation: a planner agent coordinates domain-specific department agents for specialized reasoning, while a summary agent synthesizes their analyses into a final decision. Critically, EMR automatically extracts correct diagnostic insights and failure-related warnings from multi-agent reasoning trajectories, incrementally updating the experience library to guide future cases. Experiments on medical reasoning benchmarks demonstrate that EMR consistently outperforms state-of-the-art medical multi-agent baselines. Further analysis reveals that the hierarchical experience enables cross-specialty generalization and transfer across diverse LLM backbones, offering a scalable and in

Abstract: A medical claim's correctness often depends not on the claim alone, but on the clinical structure around it. A claim may require a lab reference range, a causal or conditional link, or patient-specific details to be judged correctly, and atom-level decomposition can fragment these dependencies, leaving the verifier with clinically incomplete claims. We reformulate medical fact-checking around snippet-level verification, where clause-grouped units preserve local clinical structure. We introduce MedSNIP-Bench, a human-annotated benchmark for snippet-level medical fact verification, and MedSNIP, an automatic snippet-generation pipeline. MedSNIP-Bench covers 276 consumer-health and clinical-vignette responses, segmented into 2,524 snippets with dual in-general and in-patient-context labels and six structural pattern codes. MedSNIP is evaluated against human snippet boundaries on MedSNIP-Bench and then used to generate snippet-level units for external corpora. Across MedSNIP-Bench, HealthFC, and MedHallu, snippet-level verification preserves or improves false-class F1, with gains concentrated where answers are long enough to fragment and where the verifier is strong enough to exploit the recovered structure. The largest merge-pattern gain is on causal-conditional clinical chains. It also reduces verifier calls by 24-73%, though the saving survives end-to-end only when decomposition is cheap, which an open-weight decomposer makes possible at no loss of chunking fidelity.

Abstract: The prevailing assumption in applied machine learning is that progress on consequential quantitative decisions such as pricing risk, allocating capital, triaging patients, or containing a network intrusion will follow from progress in large language models (LLMs). A language model is trained on a representation of the world that was produced by human description; description is a lossy encoding of the quantitative record, and the loss is irreversible: no downstream model, at any scale, can recover from a description what the description did not encode. We formalize this as a property of the representation on which a model is trained rather than of the model capacity, and we identify three further properties that consequential settings demand of a model and that a language substrate cannot supply by construction: reproducibility, lineage from every output back to the source records that produced. it, and calibrated uncertainty. We argue that these properties define a distinct model class, which we call the Large Quantitative Model (LQM).

Abstract: Cardiovascular screening models trained on national health surveys routinely report areas under the receiver operating characteristic curve (AUROC) near 0.89. We asked whether that accuracy reflects learning or target leakage, whether tabular foundation models change the answer, and whether the properties deployment requires survive joint examination. We benchmarked ten classifiers spanning linear, tree-ensemble, neural, glass-box, and tabular foundation classes for prevalent myocardial infarction in 442,067 respondents of the 2022 Behavioral Risk Factor Surveillance System across five feature tiers of decreasing leakage risk. Each was audited for discrimination, calibration, fairness at an explicit screening threshold, conformal coverage, explanation faithfulness, and inference cost, then applied -- models and thresholds frozen -- to 430,755 respondents of 2023. Removing two post-diagnostic features cost every model 0.049-0.051 AUROC, collapsing the field into a 0.0045-wide band. The glass-box explainable boosting machine was non-inferior to every alternative within a pre-specified 0.005 margin while scoring the cohort roughly 104 times faster than the strongest foundation model. One threshold detected 75.4% of women's infarctions against 89.0% of men's; editing the model's shape functions reduced the gap to 0.010. Marginal conformal prediction gave 0.86 coverage to men and 0.82 to adults over 60; Mondrian calibration repaired every stratum. Frozen models transported within 0.002 AUROC. Reported headroom in this literature is a property of the feature set, not the learner. Transparency cost nothing measurable and made fairness repair and uncertainty conditioning directly auditable. Evaluation practice, not model capacity, is the binding constraint.

Abstract: Oncology care operates at constant pressure of absorbing rapidly evolving evidence base in biomedicine. The American Society of Clinical Oncology (ASCO) addresses this through living guidelines, but the format introduces a new burden: any recommendation can change at any point, across multiple versioned documents. We present SENTRYLINE, a living guideline-aware clinical question answering system. SENTRYLINE retrieves guideline passages through a vectorless hierarchical RAG pipeline and returns a role-specific answer with inline citations, factual and temporal verification reports, and drift detection notes that surface when a guideline has been updated. We construct ASCOBENCH, a benchmark of 405 three-turn conversations across four question categories with gold answers from expert annotators(clinicians), and use test set to evaluate SENTRYLINE against five baselines under an LLM-as-judge framework. Experiments across three generation backbones show consistent improvements over four retrieval baselines and ASCO's guideline assistant, with particularly strong gains on Reasoning and Role-Specific questions where multi-hop synthesis and register adaptation are required